Hao Feng

Black carp DDX3b suppresses antiviral immunity by inhibiting IRF7 modifications and promoting its lysosomal degradation

Liang Chen, Ziting Zhao, Zhihao Du, Xinyi Liang et autres

cn (code pays fourni par la source)

TANK potentiates antiviral innate immunity by recruiting deubiquitinase USP46 to activate IKKε

Zhenghao Li, Can Yang, Juanjuan Shu, Yi-Xiang Wang et autres

IKKε plays an important role in interferon (IFN) production, however, its regulation remains poorly understood. In this study, we demonstrate that black carp TANK (bcTANK) interacts with bcIKKε and significantly enhances its activation of bcIRF3 and bcIRF7, leading to the improved antiviral …

cn (code pays fourni par la source)

Negative regulation of RIG-I by STAT1a and STAT1b in the innate immunity of black carp

Keqing Wang, Chushan Dai, Tian Qin, Jiaxin Wang et autres

cn (code pays fourni par la source)

Establishment and antiviral immune response characterization of fin cell lines from black carp (Mylopharyngodon piceus) and gynogenetic black carp

Wei Qin, Linxi Cai, Mengru Liu, Yu Tan et autres

cn (code pays fourni par la source)

UEV1A attenuates MDA5-mediated antiviral immune response by reducing its ubiquitination and aggregation

Jiaxin Wang, Ruoyao Sun, Ting Li, Houcheng Liang et autres

cn (code pays fourni par la source)

An end-to-end dual backbone framework for UAV fish disease detection using optimized GateHCO feature fusion mechanism

Jiaji Pan, Zehui Liu, Xuanzhi Li, Xianwu Luo et autres

cn, hk, gb (code pays fourni par la source)

Black carp STAT2 inhibits IRF7-mediated antiviral response by altering its ubiquitination and nuclear transfer

Ruoyao Sun, Xinyu Wang, Zhuo Fang, Zhan'ao Li et autres

cn (code pays fourni par la source)

Ubiquitin-specific protease 14 inhibition promotes mitophagy and attenuates neural apoptosis after spinal cord injury

Dingwei Wu, Dehui Chen, Huina Chen, Zhengxi Yu et autres

Spinal cord injury (SCI) is a devastating condition characterized by severe neurological deficits and limited recovery, primarily due to the intricate cascade of secondary injury mechanisms. Post-SCI mitochondrial dysfunction can lead to increased oxidative stress and neuronal apoptosis. This study aimed to …

cn (code pays fourni par la source)

Proteomic insights into antiviral immunity: Comparative analysis of diploid, triploid, and allotetraploid cells reveals ploidy-specific defense mechanisms against SVCV infection

Dan Zeng, Kai Yao, Xiaoxin Luke Chen, Gongwei Sun et autres

While triploid fish (3 n = 150) exhibited superior antiviral capability relative to both diploid (2 n = 100) and allotetraploid (4 n = 200) progenitors, the molecular basis for this enhanced resistance remained poorly characterized. This study explored the proteomic responses …

cn (code pays fourni par la source)

DEAD-box helicase gcDDX56 disrupts IRF3 nuclear import complex and promotes nuclear IRF3 degradation for enhancing GCRV replication

Xiao Li, Yang Chen, Jie Zhang, Jun Xiao et autres

ABSTRACT DEAD-box helicases play multifaceted roles in antiviral immunity, acting as both viral sensors and regulators of interferon (IFN) signaling. However, the role of DDX56 in teleost antiviral immunity remains poorly characterized. This study investigates the role of grass carp DDX56 (gcDDX56) …

cn (code pays fourni par la source)

Black carp STAT2 enhances IRF3-mediated antiviral signaling by regulating its ubiquitination and improving its nuclear translocation

Xinyu Wang, Jinyi Li, Ting Li, Xiaoyu Liu et autres

cn (code pays fourni par la source)

Zebrafish TRIM2a promotes virus replication via ubiquitination of IRF3 and autophagic cargo receptor p62

Wenji Huang, Wang Yf, Ning Ji, Hehe Xiao et autres

A balanced IFN response, tightly regulated at multiple levels, is essential for host defense against viral infection. Tripartite motif-containing (TRIM) proteins are a large group of E3 ubiquitin ligases, and have been shown to be involved in the regulation of IFN response. …

cn, me (code pays fourni par la source)