Jian-Hua Fu

Mechanism of Shuangshen Xionglian Granule in Attenuating EndMT in Atherosclerosis via the FGFR1–TGF‐β/Smad2 Axis

Xinyi Cui, Hailang Luo, Ran Zhang, Yuanyuan Chen et autres

ABSTRACT Shuangshen Xionglian Granule (SSXL), a multi‐herb traditional Chinese medicine used for atherosclerosis (AS), was investigated for its anti‐atherosclerotic effects and its role in modulating endothelial‐to‐mesenchymal transition (EndMT). In high‐fat diet–fed ApoE −/− mice, SSXL ameliorated dyslipidemia, reduced systemic inflammation, and alleviated …

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Lipid metabolic reprogramming in myocardial ischaemia/reperfusion injury: mechanisms and therapeutic opportunities

Li Lanlan, Chen Yuanyuan, Guo Fan, Xiaoqing Zhang et autres

Myocardial ischaemia/reperfusion injury limits myocardial salvage after acute coronary occlusion. Although reperfusion is essential, the return of oxygen and substrates also exposes previously ischaemic myocardium to abrupt oxidative, ionic, microvascular, and inflammatory stress. Lipid handling is increasingly recognised as one important setting …

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SIRT3-mediated deacetylation of ATP5A1 improves mitochondrial function to attenuate myocardial ischemia-reperfusion injury

Yuanyuan Chen, Gaojie Xin, Huiyu Zhang, Xinyi Cui et autres

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[Alleviation of hypoxia/reoxygenation injury in HL-1 cells by ginsenoside Rg_1 via regulating mitochondrial fusion based on Notch1 signaling pathway].

Huiyu Zhang, Xiaoshan Cui, Yuanyuan Chen, Gaojie Xin et autres

This paper explored the specific mechanism of ginsenoside Rg_1 in regulating mitochondrial fusion through the neurogenic gene Notch homologous protein 1(Notch1) pathway to alleviate hypoxia/reoxygenation(H/R) injury in HL-1 cells. The relative viability of HL-1 cells after six hours of hypoxia and two …

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Corrigendum to “Shuangshen ningxin formula attenuates cardiac microvascular ischemia/reperfusion injury through improving mitochondrial function” [J. Ethnopharmacol. 323 (2024) 117690]

ZiXin Liu, Xiao Han, Yue You, Gaojie Xin et autres

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Mitophagy in ischemic heart disease: molecular mechanisms and clinical management

Shujuan Xu, Zihan Wang, Fan Guo, Yehao Zhang et autres

The influence of the mitochondrial control system on ischemic heart disease has become a major focus of current research. Mitophagy, as a very crucial part of the mitochondrial control system, plays a special role in ischemic heart disease, unlike mitochondrial dynamics. The …

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[Mechanism of ginsenoside Rg_1 in regulating autophagy through miR-155/Notch1/Hes1 pathway to attenuate hypoxia/reoxygenation injury in HL-1 cells].

Huiyu Zhang, Gaojie Xin, Yuanyuan Chen, Ce Cao et autres

This article explored the specific mechanism by which ginsenoside Rg_1 regulates cellular autophagy to attenuate hypoxia/reoxygenation(H/R) injury in HL-1 cardiomyocytes through the microRNA155(miR-155)/neurogenic gene Notch homologous protein 1(Notch1)/hairy and enhancer of split 1(Hes1) pathway. An HL-1 cell model with H/R injury was …

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[Mechanism of Tanyu Tongzhi Formula in treatment of atherosclerosis by maintaining vascular homeostasis based on TGF-β signaling pathway].

Xiaoshan Cui, Huiyu Zhang, Yuan Yuan Chen, Liang Li et autres

This study aimed to investigate the potential mechanism and the compatibility significance of Tanyu Tongzhi Formula in treating atherosclerosis(AS) in mice based on the transforming growth factor-β(TGF-β)/Smad2/3 signaling pathway. Eight C57BL/6J mice were as assigned to a normal control group and fed …

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Adverse pregnancy outcomes and multiple cancers risk in both mother and offspring: an umbrella review of systematic reviews with meta-analyses of observational studies

Na Liu, Rui-Han Bao, Yu-Jiao Chang, Fang-Hua Liu et autres

BACKGROUND: Adverse pregnancy outcomes have reached epidemic proportions in recent years with serious health ramifications, especially for diverse cancers risk. Therefore, we carried out an umbrella review to systematically evaluate the validity and strength of the data and the extent of potential …

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Qingfei Zhisou oral liquid alleviates fever-induced inflammation by regulating arachidonic acid and lysophospholipids metabolism and inhibiting hypothalamus transient receptor potential ion channels expression.

Gao Jiaming, Yehao Zhang, Yuanyuan Chen, Jin Long et autres

OBJECTIVE: To explore how Qingfei Zhisou oral liquid (, QFZS) adjusts body temperature bias and the interaction of inflammatory factors levels and metabolomic differences. METHODS: Dry yeast was subcutaneously injected at 10 mL/kg to establish the pyrexia model. We randomly divided 60 …

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[Ginsenoside Rg_1 modulates ATP5A1 deacetylation via SIRT3 to attenuate hypoxia/reoxygenation injury in HL-1 cardiomyocytes].

Yuanyuan Chen, Gaojie Xin, Zixin Liu, Huiyu Zhang et autres

This study investigated the mechanism by which ginsenoside Rg_(1 )attenuates hypoxia/reoxygenation(H/R) injury in HL-1 cardiomyocytes by inhibiting the acetylation of ATP synthase subunit alpha(ATP5A1) through silent information regulator 3(SIRT3). In this study, an H/R injury model was constructed by hypoxia for 6 …

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Research Progress on the Mechanism, Monitoring, and Prevention of Cardiac Injury Caused by Antineoplastic Drugs—Anthracyclines

Yuanyuan Chen, Wenwen Yang, Xiaoshan Cui, Liang Li et autres

Anthracyclines represent a highly efficacious class of chemotherapeutic agents employed extensively in antitumor therapy. They are universally recognized for their potency in treating diverse malignancies, encompassing breast cancer, gastrointestinal tumors, and lymphomas. Nevertheless, the accumulation of anthracyclines within the body can lead …

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