Sunil Kumar Sinha

Two-year outcomes after selective early treatment of patent ductus arteriosus with ibuprofen in preterm babies: follow-up of Baby-OSCAR–a randomised controlled trial

Samir Gupta, Heather O’Connor, Edmund Juszczak, Nim V. Subhedar et autres

Background: Children born extremely preterm are at increased risk of developmental problems and respiratory morbidity due to patent ductus arteriosus (PDA). The objective of this study was to evaluate whether early treatment of a PDA ≥1.5 mm with ibuprofen improved neurodevelopmental and …

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Economic Evaluation alongside the Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen in Extreme Preterm Babies

Chidubem B. Ogwulu, Mark Monahan, Samir Gupta, Nim V. Subhedar et autres

Abstract Objective To conduct an economic evaluation alongside the placebo-controlled trial of selective early treatment of patent ductus arteriosus with ibuprofen in extreme preterm babies. Design Within-trial economic evaluation alongside a multicentre, randomized, masked, placebo-controlled trial. Setting Thirty-two UK tertiary neonatal intensive …

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Digital twins enable stratification of persistent atrial fibrillation patients for ablation diminishing unnecessary heart damage

Kensuke Sakata, Carolyna Yamamoto Alves Pinto, Adityo Prakosa, Brock M. Tice et autres

Pulmonary vein isolation (PVI), the standard-of-care for atrial fibrillation (AF), is effective even in some persistent AF (PsAF) patients despite atrial fibrosis proliferation, suggesting that PVI could not only be isolating triggers but diminishing arrhythmogenic substrates. Left atrial (LA) posterior wall isolation …

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Two-Year Outcomes after Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen in Preterm Babies. Follow-Up of Baby-OSCAR - A Randomised Controlled Trial

Samir Gupta, Edmund Juszczak, Nim V. Subhedar, Ursula Bowler et autres

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QRS prolongation is associated with adverse cardiac remodeling in hypertrophic cardiomyopathy

Hernán L Vera-Sarmiento, Talha Tanriverdi, David Hurtado-de-Mendoza, Sanjay Sivalokanathan et autres

BACKGROUND: Signal-averaged electrocardiogram (SAECG) records myocardial depolarization, and can detect inhomogeneous/slow conduction in fibrotic myocardium, which promotes reentrant ventricular arrhythmias (VAs). Hypertrophic cardiomyopathy (HCM) is associated with a high prevalence of cardiac fibrosis and VAs, but abnormal SAECG has low predictive power …

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Unipolar voltage electroanatomic mapping detects structural atrial remodeling identified by LGE-MRI

Syed Yusuf Ali, Yazan Mohsen, Yuncong Mao, Kensuke Sakata et autres

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Unipolar electroanatomical mapping outperforms bipolar voltage in detecting LGE areas in the left atrium

Yazan Mohsen, Syed Zulfiqar Ali, Yushan Mao, Adityo Prakosa et autres

Abstract Introduction In atrial fibrillation (AF) management, understanding left atrial substrate is crucial. While both electroanatomical mapping (EAM) and late gadolinium enhancement MRI (LGE MRI) are reliable methods in assessing atrial substrate and are associated with the ablation outcome, recent findings have …

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Optimizing the Distribution of Ablation Lesions to Prevent Postablation Atrial Tachycardia

Kensuke Sakata, Ryan P. Bradley, Adityo Prakosa, Carolyna Yamamoto Alves Pinto et autres

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Assessing the arrhythmogenic propensity of fibrotic substrate using digital twins to inform a mechanisms-based atrial fibrillation ablation strategy

Kensuke Sakata, Ryan P. Bradley, Adityo Prakosa, Carolyna Yamamoto Alves Pinto et autres

Atrial fibrillation (AF), the most common heart rhythm disorder, may cause stroke and heart failure. For patients with persistent AF with fibrosis proliferation, the standard AF treatment-pulmonary vein isolation-has poor outcomes, necessitating redo procedures, owing to insufficient understanding of what constitutes good …

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QRS prolongation is associated with structural remodeling in hypertrophic cardiomyopathy

Hernán L Vera-Sarmiento, Talha Tanriverdi, David Hurtado-de-Mendoza, Sanjay Sivalokanathan et autres

ABSTRACT Background Signal-averaged electrocardiogram (SAECG) records myocardial depolarization, and can detect inhomogeneous/slow conduction in fibrotic myocardium, which promotes reentrant ventricular arrhythmias (VAs). Hypertrophic cardiomyopathy (HCM) is associated with a high prevalence of cardiac fibrosis and VAs, but abnormal SAECG has low predictive …

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Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen

Samir Gupta, Nim V. Subhedar, Jennifer Bell, David J Field et autres

BACKGROUND: The cyclooxygenase inhibitor ibuprofen may be used to treat patent ductus arteriosus (PDA) in preterm infants. Whether selective early treatment of large PDAs with ibuprofen would improve short-term outcomes is not known. METHODS: We conducted a multicenter, randomized, double-blind, placebo-controlled trial …

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Abstract 18098: Prolonged Filtered QRS Duration on Signal Averaged Electrocardiogram is Associated With Structural Remodeling in Hypertrophic Cardiomyopathy

Hernan L Vera Sarmiento, Talha Tanriverdi, David Hurtado-de-Mendoza, Sanjay Sivalokanathan et autres

Background: Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy, electrical remodeling and fibrosis that lead to inhomogeneous ventricular depolarization and arrhythmias. Signal averaged ECG (SAECG) is useful for non-invasive risk stratification in ischemic cardiomyopathy. However, the association between SAECG and structural remodeling …

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