Accès ouvert
2025
article
OpenAlex
Georgios Kanellos, Chiara Giacomelli, Alexander Raven, Nikola Vlahov et autres
Nucleophosmin (NPM1), a nucleolar protein frequently mutated in hematopoietic malignancies, is overexpressed in several solid tumors with poorly understood functional roles. Here, we demonstrate that Npm1 is upregulated after APC loss in WNT-responsive tissues and supports WNT-driven intestinal and liver tumorigenesis. Mechanistically, …
gb, us
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Accès ouvert
2025
article
OpenAlex
Mark White, Megan L. Mills, Laura M. Millett, Kathryn Gilroy et autres
Abstract The colorectal epithelium is rapidly renewing, with remarkable capacity to regenerate following injury. In colorectal cancer (CRC), this regenerative capacity can be co-opted to drive epithelial plasticity. Although oncogenic MAPK signalling in CRC is common, with frequent mutations of both KRAS …
gb, be, de
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Accès ouvert
2025
article
OpenAlex
Celine I Wittke, Eric C. Cheung, Dimitris Athineos, Nicola Clements et autres
Background & Aims TP53 is a potent tumour suppressor that coordinates diverse stress response programmes, ranging from pro-survival activities to cell death. p53 is also engaged during tissue damage and repair, including within the liver. Metabolic dysfunction-associated steatohepatitis (MASH) is a major …
gb
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Accès ouvert
2024
preprint
OpenAlex
Celine I Wittke, Eric C. Cheung, Dimitris Athineos, Nicola Clements et autres
ABSTRACT TP53 is a potent tumour suppressor that coordinates diverse stress response programmes within the cell. The activity of p53 is frequently context and cell type-dependent, and ranges from pro-survival activities, including the implementation of transient cell cycle arrest and metabolic rewiring, …
gb
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