Accès ouvert
2025
conference-abstract
OpenAlex
Fabio Efficace, Elisa Diral, Daniela Krepper, Corrado Campochiaro et autres
Abstract Background VEXAS is a recently discovered rare disease with a broad spectrum of clinical manifestations. Particularly, the disease is associated with a diagnosis of myelodysplastic syndrome/neoplasm (MDS) in up to 30-60% of cases. To date, no guidelines exist for its clinical …
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Accès ouvert
2025
article
OpenAlex
Vasiliki Liakouli, Giulio Forte, Piero Ruscitti, Luca Navarini et autres
OBJECTIVE: To assess the contribution of Systemic sclerosis (SSc)-specific features on type II diabetes mellitus (T2D) in a large cohort of Italian SSc patients. METHODS: A total of 613 SSc patients from 11 tertiary Rheumatology Units across Italy were included. All patients …
it
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2024
article
OpenAlex
Carmelo Gurnari, Elisa Galossi, Eleonora Lumia, Alfonso Piciocchi et autres
Vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic (VEXAS) is a haemato-inflammatory syndrome genetically defined by somatic mutations in the X-linked UBA1 gene, typically Val/Thr/Leu substitutions at the Met41 hotspot. Clinical manifestations are heterogeneous and refractory to most haemato-rheumatological treatments. To date, no guidelines …
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Accès ouvert
2024
conference-abstract
OpenAlex
Carmelo Gurnari, Elisa Galossi, Eleonora Lumia, Alfonso Piciocchi et autres
VEXAS is a hemato-inflammatory syndrome genetically defined by somatic mutations in the X-linked UBA1 gene in hematopoietic precursor cells. Val/Thr/Leu substitutions at the Met41 hotspot constitute the molecular underpinnings of VEXAS in more than 90% of patients, typically men during the 6-7th …
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Accès ouvert
2024
article
OpenAlex
Vasiliki Liakouli, Ignazio Verde, Piero Ruscitti, Claudio Di Vico et autres
OBJECTIVES: Conflicting results about clinical and subclinical atherosclerosis in systemic sclerosis (SSc) and the associated risk factors have been reported. Hence, we aimed to determine the prevalence of clinical and subclinical atherosclerosis in a large number of Italian SSc patients and the …
it, es, us
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Accès ouvert
2024
article
OpenAlex
Jurgen Sota, Silvana Guerriero, Giuseppe Lopalco, Abdurrahman Tufan et autres
Purpose The clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Behçet’s disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown.Methods Data were prospectively collected from the International AIDA Network Registry for BD and for …
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Accès ouvert
2023
article
OpenAlex
Rosaria Talarico, Giuseppe A. Ramirez, Sofia Barreira, Chiara Cardamone et autres
Recent studies have shown that people who are immunocompromised may inadvertently play a role in spurring the mutations of the virus that create new variants. This is because some immunocompromised individuals remain at risk of getting COVID-19 despite vaccination, experience more severe …
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