CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion
J.-M. Lee, E.M. Ramos, J.-H. Lee, Tammy Gillis et autres
OBJECTIVE: Age at onset of diagnostic motor manifestations in Huntington disease (HD) is strongly correlated with an expanded CAG trinucleotide repeat. The length of the normal CAG repeat allele has been reported also to influence age at onset, in interaction with the …
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397 citations
Neurology