Domenico Lione

Drug-related hepatotoxicity risk in elderly patients with atrial fibrillation: insights from the nationwide Italian START registry

Gianluca Gazzaniga, Danilo Menichelli, Daniela Poli, Gualtiero Palareti et autres

Atrial fibrillation (AF) patients frequently require polypharmacy, increasing the risk of drug-drug interactions and hepatotoxicity. We analyzed the use of drugs potentially associated with liver injury in anticoagulated AF patients. We applied the LiverTox classification to AF patients from the START registry, …

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Real-world use of direct oral anticoagulants in atrial fibrillation patients with moderate/severe chronic kidney disease: a propensity score matched analysis from the START registry

Danilo Menichelli, Gianluca Gazzaniga, Daniela Poli, Gualtiero Palareti et autres

BACKGROUND: Chronic kidney disease (CKD) often coexists in patients with atrial fibrillation (AF), worsening patients' prognosis. Direct oral anticoagulants (DOACs) are increasingly used also in patients with AF and CKD, but limited evidence exists regarding outcomes in advanced CKD. METHODS: . The …

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Atrial Fibrillation, Heart Failure Phenotypes, and Mortality Risk in the Nationwide START Registry: A Propensity Score Matching Analysis

Danilo Menichelli, Emilia Antonucci, Gianluca Gazzaniga, Daniela Poli et autres

Background Data on atrial fibrillation (AF) and heart failure (HF) with preserved ejection fraction (HFpEF) are scarce. We investigated the association of HFpEF with all‐cause mortality in AF. Methods We included 10 369 patients with AF on oral anticoagulants from the nationwide …

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Inappropriate Underdosing of Direct Oral Anticoagulants in Atrial Fibrillation Patients: Results from the START2-AF Registry

Daniela Poli, Emilia Antonucci, Walter Ageno, Martina Berteotti et autres

Background: Direct oral anticoagulants (DOACs) are recommended for stroke prevention in non-valvular atrial fibrillation (NVAF) patients. We aimed to describe the prevalence of inappropriate DOACs dose prescription in the START2-AF Registry, the outcomes according to the appropriateness of the dosage, and the …

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Statins under-treatment and mortality in patients with atrial fibrillation. Insights from the nationwide START registry

Danilo Menichelli, Emilia Antonucci, Pasquale Pignatelli, Francesco Violi et autres

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Management of anticoagulation in atrial fibrillation patients in Italy: insight from the Atrial Fibrillation-Survey on Anticoagulated Patients Register (AF-START)

Daniela Poli, Walter Ageno, Emilia Antonucci, Salvatore Bradamante et autres

The survey on anticoagulated patients register (START-Register) is an independent, prospective, inception-cohort observational study aimed at providing information on patients on vitamin K antagonists (VKAs) or direct oral anticoagulants (DOACs) in Italy. In this study, we describe the cohort of atrial fibrillation …

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Thrombocytopenia and Mortality Risk in Patients With Atrial Fibrillation: An Analysis From the START Registry

Daniele Pastori, Emilia Antonucci, Francesco Violi, Gualtiero Palareti et autres

Background Thrombocytopenia is associated with increased mortality in the general population, but few data exist in patients with atrial fibrillation ( AF ) taking oral anticoagulants. We investigated factor determinants of thrombocytopenia in a large cohort of patients affected by AF and …

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