Accès ouvert
2024
article
OpenAlex
Hisano Yajima, Yuki Anraku, Yu Kaku, Kanako Kimura et autres
Since 2019, SARS-CoV-2 has undergone mutations, resulting in pandemic and epidemic waves. The SARS-CoV-2 spike protein, crucial for cellular entry, binds to the ACE2 receptor exclusively when its receptor-binding domain (RBD) adopts the up-conformation. However, whether ACE2 also interacts with the RBD …
jp, cz
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Accès ouvert
2024
article
OpenAlex
Yusuke Kosugi, Arnon Plianchaisuk, Olivia Putri, Keiya Uriu et autres
As of November, 2023, SARS-CoV-2 XBB variants, including EG.5.1 (XBB.1.9.2.5.1), the currently predominant lineage, have been circulating worldwide, according to Nextstrain datasets. The EG.5.1 strain has a characteristic amino acid substitution in the spike protein (S; S:F456L), which allows the strain to …
jp, id
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Accès ouvert
2023
article
OpenAlex
Shigeru Fujita, Keiya Uriu, Lin Pan, Naganori Nao et autres
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants has led to concerns that ancestral SARS-CoV-2-based vaccines may not be effective against newly emerging Omicron subvariants. The concept of "imprinted immunity" suggests that individuals vaccinated with ancestral virus-based vaccines …
jp
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