Engineering Toxoplasma gondii secretion systems for intracellular delivery of multiple large therapeutic proteins to neurons
Shahar Bracha, Hannah J. Johnson, Nicole A. Pranckevicius, Francesca Catto et autres
Delivering macromolecules across biological barriers such as the blood-brain barrier limits their application in vivo. Previous work has demonstrated that Toxoplasma gondii, a parasite that naturally travels from the human gut to the central nervous system (CNS), can deliver proteins to host …
us, il, gb, ch, it (code pays fourni par la source)
29 citations
Nature Microbiology