Accès ouvert
2024
article
OpenAlex
Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan et autres
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited.Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and …
de, nl, gb, it, es
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Accès ouvert
2023
article
OpenAlex
Shea J. Andrews, Mattia Cordioli, Christine Stevens, Mark J. Daly et autres
Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1 , 2 . Here we present a second updated genome-wide association study (GWAS) …
us, fi, pl, my, ch, gb, Burkina Faso, ca, pr, it, in, Égypte, es, nl, Afrique du Sud, cl, hu, br, fr, be, mx, au, de, jp, py
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Accès ouvert
2023
erratum
OpenAlex
Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres
In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.
gb, cn, au, ca, ie, hk, es, mx, nl
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Accès ouvert
2023
article
OpenAlex
Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres
Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . Despite the advanced stage of illness at presentation, we have shown that …
gb, cn, au, ca, ie, hk, es, mx, nl
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Accès ouvert
2022
article
OpenAlex
Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, A. Stuckey et autres
after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically …
gb, au, cn, ca, ie, us, hk, Ouganda, br
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Accès ouvert
2021
article
OpenAlex
Chiara Fallerini, Nicola Picchiotti, Margherita Baldassarri, Kristina Zguro et autres
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 …
it, se, fr, at, be, ca, gb, de
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Accès ouvert
2021
article
OpenAlex
Mari Niemi, Juha Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres
Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …
fi, us, es, de, it, gb, nl, ca, kr, jp, ae, fr, au, pl, in, be, qa, dk, cl, pr, mx
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