T.S. Ahluwalia

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity

Raimo Joro, John A. Curtin, R.L. Hanson, Niina Pitkänen et autres

Although hundreds of genome-wide association studies-implicated loci have been reported for adult obesity-related traits, less is known about the genetics specific for early-onset obesity and with only a few studies conducted in non-European populations to date. Searching for additional genetic variants associated …

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Meta-analysis of exome array data identifies six novel genetic loci for lung function

David J. Porteous, André G. Uitterlinden, George O'connor, Jonathan Marten et autres

Background: Over 90 regions of the genome have been associated with lung function to date, many of which have also been implicated in chronic obstructive pulmonary disease. Methods: We carried out meta-analyses of exome array data and three lung function measures: forced …

Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function

D. Hu, Patricia A. Cassano, E.G. Holliday, Tianxiao Huan et autres

Nearly 100 loci have been identified for pulmonary function, almost exclusively in studies of European ancestry populations. We extend previous research by meta-analyzing genome-wide association studies of 1000 Genomes imputed variants in relation to pulmonary function in a multiethnic population of 90,715 …

58th EASD Annual Meeting of the European Association for the Study of Diabetes

Sule Altintas, G. Bouland, A. Veluchamy, M. Thangam et autres

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Genome-Wide Association Study of Apparent Treatment-Resistant Hypertension in the CHARGE Consortium: The CHARGE Pharmacogenetics Working Group

A. Correa, E.A. Whitsel, H.R. Warren, N. Limdi et autres

BACKGROUND: Only a handful of genetic discovery efforts in apparent treatment-resistant hypertension (aTRH) have been described. METHODS: We conducted a case-control genome-wide association study of aTRH among persons treated for hypertension, using data from 10 cohorts of European ancestry (EA) and 5 …

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Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits

S.E. Harris, J. Corley, M.K. Wojczynski, M. Nauck et autres

Mitochondria (MT), the major site of cellular energy production, are under dual genetic control by 37 mitochondrial DNA (mtDNA) genes and numerous nuclear genes (MT-nDNA). In the CHARGEmtDNA+ Consortium, we studied genetic associations of mtDNA and MT-nDNA associations with body mass index …

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