Pierre-Yves Plaçais

Aversive learning hijacks a brain sugar sensor to consolidate memory

Raquel Francés, Typhaine Comyn, Coraline Desnous, Francesca Bettoni et autres

The formation of food-related memories involves post-ingestion nutrient sensing signals1–5. Whether nutrient sensors act beyond feeding-relevant behaviour is less well understood. Here we show that an internal sugar sensor in the Drosophila brain6 is involved in memory consolidation, both in fasted flies …

fr (code pays fourni par la source)

Mitochondrial Ca2+ efflux controls neuronal metabolism and long-term memory across species

Anjali Amrapali Vishwanath, Typhaine Comyn, Rodrigo G. Mira, Claire Brossier et autres

Abstract From insects to mammals, essential brain functions, such as forming long-term memories (LTMs), increase metabolic activity in stimulated neurons to meet the energetic demand associated with brain activation. However, while impairing neuronal metabolism limits brain performance, whether expanding the metabolic capacity …

fr, at, es, us (code pays fourni par la source)

Author response: In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the Drosophila mushroom body

Philémon Roussel, Mingyi Zhou, Chiara Stringari, Thomas Préat et autres

fr, Maroc (code pays fourni par la source)

In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the Drosophila mushroom body

Philémon Roussel, Mingyi Zhou, Chiara Stringari, Thomas Préat et autres

Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-free and minimally invasive technique, fluorescence lifetime imaging (FLIM) of coenzymes NADH …

fr (code pays fourni par la source)

In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the Drosophila mushroom body

Philémon Roussel, Mingyi Zhou, Chiara Stringari, Thomas Préat et autres

Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-free and minimally invasive technique, fluorescence lifetime imaging (FLIM) of coenzymes NADH …

fr (code pays fourni par la source)

Neuronal fatty acid oxidation fuels memory after intensive learning in Drosophila

Alice Pavlowsky, Bryon Silva, Ruchira Basu, Amandine Correia Delecourt et autres

. In contrast, neurons, which are major energy consumers, are considered to rely essentially on glucose and its derivatives to support their metabolism. Here, using Drosophila melanogaster, we show that memory formed after intensive massed training is dependent on mitochondrial fatty acid …

fr (code pays fourni par la source)

Embracing the Modern Biochemistry of Brain Metabolism

Juan Pedro Bolaños, Cristina M. Alberini, Ángeles Almeida, L. Felipe Barros et autres

This editorial challenges the long-held neuron-centered view of brain metabolism, relying on ample evidence that it is a cooperative, multicellular process. Astrocytes, oligodendrocytes, and other glia play active roles providing lactate, antioxidant support, and substrate shuttles that fuel neuronal function and memory. …

es, us, cl, fr, de, gb, sa, ch, br (code pays fourni par la source)

In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the Drosophila mushroom body

Philémon Roussel, Mingyi Zhou, Chiara Stringari, Thomas Préat et autres

Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-free and minimally invasive technique, fluorescence lifetime imaging (FLIM) of coenzymes NADH …

fr (code pays fourni par la source)

In vivo autofluorescence lifetime imaging of the Drosophila brain captures metabolic shifts associated with memory formation

Philémon Roussel, Mingyi Zhou, Chiara Stringari, Thomas Préat et autres

Abstract Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-free and minimally invasive technique, fluorescence lifetime imaging (FLIM) of coenzymes …

fr (code pays fourni par la source)

Author response: In vivo autofluorescence lifetime imaging of the Drosophila brain captures metabolic shifts associated with memory formation

Philémon Roussel, Mingyi Zhou, Chiara Stringari, Thomas Préat et autres

Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-free and minimally invasive technique, fluorescence lifetime imaging (FLIM) of coenzymes NADH …

fr (code pays fourni par la source)

In vivo autofluorescence lifetime imaging of spatial metabolic heterogeneities and learning-induced changes in the Drosophila mushroom body

Philémon Roussel, Mingyi Zhou, Chiara Stringari, Thomas Préat et autres

Abstract Neuronal energy regulation is increasingly recognized as a critical factor underlying brain functions and their pathological alterations, yet the metabolic dynamics that accompany cognitive processes remain poorly understood. As a label-free and minimally invasive technique, fluorescence lifetime imaging (FLIM) of coenzymes …

fr (code pays fourni par la source)

Astrocyte-to-neuron H2O2 signalling supports long-term memory formation in Drosophila and is impaired in an Alzheimer’s disease model

Yasmine Rabah, Jean-Paul Berwick, Nisrine Sagar, Laure Pasquer et autres

Abstract Astrocytes help protect neurons from potential damage caused by reactive oxygen species (ROS). While ROS can also exert beneficial effects, it remains unknown how neuronal ROS signalling is activated during memory formation, and whether astrocytes play a role in this process. …

fr (code pays fourni par la source)