David Liebetanz

Mutual reinforcement of lymphotoxin-driven myositis and impaired autophagy in murine muscle

Juliane Bremer, Judith Nagel, Jana Zschüntzsch, Kamil K. Zajt et autres

Inclusion body myositis (IBM) is a progressive muscle disorder characterized by inflammation and degeneration with altered proteostasis. To better understand the interrelationship between these two features, we aimed to establish a novel preclinical mouse model. First, we used quantitative PCR, in situ …

04PNovel mouse model for inclusion body myositis: transgenic upregulation of lymphotoxin together with impaired autophagy induces inflammation and protein accumulation in skeletal muscle

Jeroen Bremer, J. Nagel, Jana Zschüntzsch, Kamil K. Zajt et autres

ch, de (code pays fourni par la source)

Mutual reinforcement of lymphotoxin-driven myositis and impaired autophagy in murine muscle

Juliane Bremer, Judith Nagel, Jana Zschüntzsch, Kamil K. Zajt et autres

Inclusion body myositis (IBM) is a progressive muscle disorder characterized by inflammation and degeneration with altered proteostasis. To better understand the interrelationship between these two features, we aimed to establish a novel preclinical mouse model. First, we used quantitative PCR, in situ …

de, ch (code pays fourni par la source)

A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise

Aditi Methi, Rezaul Islam, Lalit Kaurani, M. Sadman Sakib et autres

Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for learning and memory. Previous research has demonstrated that exercise-mediated improvement of learning and memory in humans and rodents correlates …

de (code pays fourni par la source)

Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study

Hannah Wilcke, Stefanie Glaubitz, Fabian Kück, Christoph Anten et autres

BACKGROUND: Myasthenia gravis (MG) affects individuals as a chronic autoimmune disease for many years. Commonly, chronic diseases significantly reduce the patients' quality of life. Aiming to improve the future quality of life in MG, this study assessed the factors impacting quality of …

de (code pays fourni par la source)

A single-cell transcriptomic analysis of the mouse hippocampus after voluntary exercise

Aditi Methi, Rezaul Islam, Lalit Kaurani, M. Sadman Sakib et autres

Abstract Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for learning and memory. Previous research has demonstrated that exercise-mediated improvement of learning and memory in humans and rodents …

de (code pays fourni par la source)

Female sex and overweight are associated with a lower quality of life in patients with myasthenia gravis: a single center cohort study

Hannah Wilcke, Stefanie Glaubitz, Fabian Kück, Christoph Anten et autres

Abstract Background: Myasthenia gravis (MG) affects individuals as a chronic paraneoplastic or autoimmune disease for many years. Commonly, chronic diseases significantly reduce the patients’ quality of life. Aiming to improve the future quality of life in MG, this study assessed the key …

de (code pays fourni par la source)

Blind identification of the spinal cord output in humans with high-density electrode arrays implanted in muscles

Silvia Muceli, Wigand Poppendieck, Aleš Holobar, Simon C. Gandevia et autres

Invasive electromyography opened a new window to explore motoneuron behavior in vivo. However, the technique is limited by the small fraction of active motoneurons that can be concurrently detected, precluding a population analysis in natural tasks. Here, we developed a high-density intramuscular …

se, de, si, au, gb (code pays fourni par la source)

Transcranial magnetic stimulation of the brain: What is stimulated? – A consensus and critical position paper

Hartwig R. Siebner, Klaus Funke, Aman S. Aberra, Andrea Antal et autres

Transcranial (electro)magnetic stimulation (TMS) is currently the method of choice to non-invasively induce neural activity in the human brain. A single transcranial stimulus induces a time-varying electric field in the brain that may evoke action potentials in cortical neurons. The spatial relationship …

dk, de, us, gb, ca, it, fr, jp, ch, au (code pays fourni par la source)

ACCURATE DECODING OF THE SPINAL CORD OUTPUT IN HUMANS WITH IMPLANTED HIGH-DENSITY ELECTRODE ARRAYS

Silvia Muceli, Wigand Poppendieck, Aleš Holobar, Simon C. Gandevia et autres

ABSTRACT Invasive electromyography opened a new window to explore motoneuron behaviour in vivo . However, the technique is limited by the small fraction of active motoneurons that can be concurrently detected, precluding a population analysis in natural tasks. Here, we developed a …

se, de, si, au, gb (code pays fourni par la source)

Intramuscular tetanus neurotoxin reverses muscle atrophy: a randomized controlled trial in dogs with spinal cord injury

Anna Kutschenko, Anja Manig, Angelika Mönnich, Beatrice Bryl et autres

BACKGROUND: Motor symptoms of spinal cord injury (SCI) considerably impair quality of life and are associated with a high risk of secondary diseases. So far, no pharmacological treatment is available for these symptoms. Therefore, we conducted a randomized, double-blinded, placebo-controlled study in …

de, us (code pays fourni par la source)

Long‐term human IgG treatment improves heart and muscle function in a mouse model of Duchenne muscular dystrophy

Jana Zschüntzsch, P. Jouvenal, Yaxin Zhang, Florian Klinker et autres

BACKGROUND: Duchenne muscular dystrophy (DMD) is a progressive muscle-wasting disease caused by mutations in the dystrophin gene, which leads to structural instability of the dystrophin-glycoprotein-complex with subsequent muscle degeneration. In addition, muscle inflammation has been implicated in disease progression and therapeutically addressed …

de (code pays fourni par la source)