Figure S2 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
Figure S2
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Rie K. Maeda
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Lung Cancer Research StudiesDNA Repair MechanismsAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryAmyotrophic Lateral Sclerosis Research
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Data from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
Abstract Cisplatin remains a cornerstone chemotherapy for many solid tumors but is limited by dose-limiting toxicities, including nephrotoxicity, peripheral neuropathy, and ototoxicity—the latter of which disproportionately affects pediatric patients and lacks effective prevention strategies. Although therapeutic approaches to mitigate cisplatin-induced toxicity are …
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Figure S1 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
Figure S1
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Figure 2 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
APE2 conditional transgenic mouse model. A, Schematic diagram of the hAPE2LSL/LSL conditional transgenic mouse model. B, Representative images of APE2 immunofluorescence staining from OHCs of Prestin-CreERT2+/−hAPE2LSL/− mice 7 days after tamoxifen injection compared with control mice without tamoxifen injection (n = 3) …
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Figure 1 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
Cisplatin treatment results in APE2 upregulation and mitochondrial dysmorphology in cochlear hair cells. A, IHC analysis of APE2 and MYH9 expression in cochlear tissues from patients with C-HL (n = 2) and normal donors (n = 1). OHCs are highlighted using blue …
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Figure 3 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
Clinical features of C-HL–like disease in APE2 transgenic mice. A, ABR thresholds, (B) DPOAE amplitudes, and (C) immunofluorescence staining (scale bar, 50 μm). D, Scanning electron microscopy (scale bar, 10 μm) in Prestin-ERT2Cre+/−hAPE2LSL/− mice (n = 6) before and after injection with …
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Figure 5 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
APE2 knockdown mitigates cisplatin-induced apoptosis in vitro.A, Knockdown of APE2 by transfection of APE2 ASO and GFP ASO as control ASO gapmers in HEI-OC1 cells. B, Flow cytometry dot plots showing Annexin V and propidium iodide staining 24 hours after transfection. The …
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Figure 7 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
APE2 inhibits p53 signaling and provokes apoptosis. HEI-OC1 cells were transfected with indicated ASO 24 hours prior to further treatments. A, Cells were treated with 1 μg/mL or 5 μg/mL cisplatin for 6 hours prior to collection of total cellular protein for …
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Figure S3 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
Figure S3
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Figure 4 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
APE2 binds to the MYH9 E853–A922 domain. A, Confocal images of HEI-OC1 cells after treatment with 250 ng/mL cisplatin at indicated time points, with DAPI (blue), APE2 (green), ATP5A (mitochondria, red), and MYH9 (magenta). Areas of condensed mitochondria with APE2–MYH9 colocalization are …
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Figure S4 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
Figure S4
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Figure 6 from Cisplatin-Induced APE2 Overexpression Disrupts MYH9 Function and Causes Hearing Loss
Qingzhu Wang, Eric Edward Irons, Wanying Zhang, Fangfang Zhao et autres
APE2 ASO restores mitochondrial respiration impaired by cisplatin treatment. A, Seahorse XF analysis of the mitochondrial OCR in cells transfected with control GFP ASO or APE2 ASO. Key parameters measured include basal respiration, ATP-linked respiration, maximal respiration, reserve capacity, proton leak, and …
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