Ursula Rauch

Cell type-specific roles of PAR1 in Coxsackievirus B3 infection

Tomohiro Kawano, Vanthana Bharathi, Yohei Hisada, Michael F. Bode et autres

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The Prognostic Role of Frailty and Its Recognition With Simple FRAIL and Fried Frailty Questionnaires in Advanced Cancer Patients

Pia Weinländer, Sara Hadzibegovic, Jan Porthun, Lucie Kretzler et autres

BACKGROUND: Patients with advanced cancer frequently suffer from frailty associated with vulnerability and adverse outcomes. Our aim was to assess the prevalence of frailty and elucidate the utility of two commonly used frailty questionnaires in an advanced cancer population. METHODS: The Fried …

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Corrigendum to “Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays” [Thromb. Res. 139 (2016) 90–97]

Raj S. Kasthuri, Yohei Hisada, Håkan Wallén, Angela M. Taylor et autres

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Measurement of microparticle tissue factor activity in clinical samples: A summary of two tissue factor-dependent FXa generation assays

Coleen A. McNamara, Fariborz Mobarrez, Yohei Hisada, Håkan Wallén et autres

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Educating healthcare professionals to improve AF-CARE: lessons from the ESC/EHRA STEEER-AF trial educational programme

Colinda van Deutekom, Karina V Bunting, Tom J. R. De Potter, Isabelle C. Van Gelder et autres

Colinda van Deutekom, Karina V Bunting, Tom J R De Potter, Isabelle C Van Gelder, Dipak Kotecha, on behalf of the, STEEER-AF education leads , Thompson Rob

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Protease-activated receptor 2 (PAR2) inhibition reduces complement-associated cardiac remodelling in obesity-related heart failure

Elham Ghanbari, Ulrike Meyer, Andrea Doerner, Margaret T. Kasner et autres

Abstract Background and Aims Obesity is considered a major risk factor for the development of heart failure (HF) due to lipid accumulation, oxidative stress and inflammation which results in cardiac remodeling. Protease activated receptor 2 (PAR2) has been linked to various cardiovascular …

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Design and deployment of the STEEER-AF trial to evaluate and improve guideline adherence: a cluster-randomized trial by the European Society of Cardiology and European Heart Rhythm Association

Maciej M. Sterlinski, Karina V Bunting, Giuseppe Boriani, Serge Bovéda et autres

AIMS: The aim is to describe the rationale, design, delivery, and baseline characteristics of the Stroke prevention and rhythm control Treatment: Evaluation of an Educational programme of the European society of cardiology in a cluster-Randomized trial in patients with Atrial Fibrillation (STEEER-AF) …

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Characterization of Biomarkers of Thrombo-Inflammation in Patients with First-Diagnosed Atrial Fibrillation

Julian Friebel, Max Wegner, Leon Blöbaum, Philipp-Alexander Schencke et autres

Patients with first-diagnosed atrial fibrillation (FDAF) exhibit major adverse cardiovascular events (MACEs) during follow-up. Preclinical models have demonstrated that thrombo-inflammation mediates adverse cardiac remodeling and atherothrombotic events. We have hypothesized that thrombin activity (FIIa) links coagulation with inflammation and cardiac fibrosis/dysfunction. Surrogate …

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Association of an impaired GH-IGF-I axis with cardiac wasting in patients with advanced cancer

Ann‐Kathrin Fröhlich, Jan Porthun, Khawaja Muhammad Talha, Alessia Lena et autres

Abstract Background Growth hormone (GH) resistance is characterized by high GH levels but low levels of insulin-like growth factor-I (IGF-I) and growth hormone binding protein (GHBP) and, for patients with chronic disease, is associated with the development of cachexia. Objectives We investigated …

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Toll-like receptor 2, hyaluronan, and neutrophils play a key role in plaque erosion: the OPTICO–ACS study

Denitsa Meteva, Ramona Vinci, Claudio Seppelt, Youssef Salah Abdelwahed et autres

BACKGROUND AND AIMS: In one-third of patients with acute coronary syndrome (ACS), thrombosis occurs despite an intact fibrous cap (IFC) (IFC-ACS, 'plaque erosion'). Recent studies emphasize neutrophils as the immediate inflammatory response in this pathology, but their exact molecular activation patterns are …

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Galectin-3 as a Marker for Increased Thrombogenicity in COVID-19

Marianna Puccini, Kai Jakobs, Leander Reinshagen, Julian Friebel et autres

Galectin-3 is a beta-galactoside-binding lectin involved in inflammation and lung fibrosis and postulated to enhance thrombosis. In COVID-19, it is considered to be a prognostic marker of severity. The aim of this study was to evaluate whether galectin-3 is associated with thrombogenicity …

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Cystic fibrosis transmembrane conductance regulator modulators attenuate platelet activation and aggregation in blood of healthy donors and COVID-19 patients

Erik Asmus, Weronika Karle, Markus C. Brack, Corey Wittig et autres

Cystic fibrosis transmembrane conductance regulator (CFTR) modulators reduce agonist-induced platelet activation and function. CFTR modulators, such as ivacaftor, present a promising therapeutic strategy in thrombocytopathies, including severe COVID-19. https://bit.ly/3HJykdt

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