Antiviral profile of hepatitis B virus capsid assembly modulator ALG-001075, the parent of pevifoscorvir sodium
Yannick Debing, Hannah Vanrusselt, Cheng Liu, Jordi Verheyen et autres
0 citationsAntiviral Research
Julian Symons
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166Publications signalées
9796Citations signalées
2Affiliations récentes
Institutions déclarées
Domaines associés
Hepatitis C virus researchHepatitis B Virus StudiesHIV/AIDS drug development and treatmentHerpesvirus Infections and TreatmentsRespiratory viral infections research
Publications récentes
Abstract 2818: Preclinical Characterization of ALG-094295, a highly potent and orally bioavailable small molecule PD-1/PD-L1 inhibitor targeting dimerization, internalization and degradation of PD-L1
Heleen Roose, Kristina Rekstyte-Matiene, Sarah Stevens, Kusum Gupta et autres
0 citationsCancer Research
Abstract 2819: Preclinical characterization of ALG-093940, a potent and orally bioavailable small molecule PD-1/PD-L1 inhibitor targeting PD-L1 dimerization, internalization and degradation
Heleen Roose, Kristina Rekstyte-Matien, Sarah Stevens, Kusum Gupta et autres
0 citationsCancer Research
Structural basis for pan-coronavirus inhibition of 3CL protease
Eswar R. Reddem, F. Forouhar, Cheng Liu, Sarah K. Stevens et autres
2 citationsStructure
Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor
Dorothée Bardiot, David C. McGowan, Kusum Gupta, Jérôme Deval et autres
4 citationsJournal of Medicinal Chemistry
THU-242 Viral kinetics and sequence analysis of a phase I monotherapy study in subjects with chronic hepatitis B reveals a high barrier of resistance to the capsid assembly modulator ALG-000184
Andreas Jekle, K. Jackson, Jacinta O’Keefe, Ros Edwards et autres
1 citationJournal of Hepatology
FRI-450 ALG-055009, a potent and selective thyroid hormone receptor beta agonist for the treatment of metabolic dysfunction-associated steatohepatitis, induces pro-metabolic and anti-fibrotic gene expression in the liver of diet-induced obese mice
Peter Althoff, Jieun Song, Lillian Adame, Tse‐I Lin et autres
1 citationJournal of Hepatology
FRI-257 Next generation hepatitis B virus antisense oligonucleotides incorporating novel chemistries demonstrated significantly improved properties compared to current clinical candidates
Jin Woo Hong, Vivek K. Rajwanshi, Jimmy Lu, Min Luo et autres
0 citationsJournal of Hepatology
The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075
Sandrine Vendeville, Franck Amblard, Leda Bassit, Leonid N. Beigelman et autres
28 citationsJournal of Medicinal Chemistry
1341 Discovery and preclinical characterization of ALG-093940, a potent and orally bioavailable small molecule PD-L1 inhibitor for the treatment of cancer
Heleen Roose, Kristina Rekstyte-Matiene, Sarah Stevens, Kusum Gupta et autres
0 citationsRegular and Young Investigator Award Abstracts
Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH
Koen Vandyck, David C. McGowan, Xuan G. Luong, Sarah Stevens et autres
35 citationsJournal of Medicinal Chemistry
TOP-357 Second generation HBV siRNAs with novel chemistries demonstrate improved profiles compared with ALG-125755 and other clinical stage siRNAs
Jin Tae Hong, Vivek K. Rajwanshi, Saul Montero, Min Luo et autres
0 citationsJournal of Hepatology
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