Dinh Nguyen Huy Man

Detection of Immunity Gap before Measles Outbreak, Ho Chi Minh City, Vietnam, 2024

Phuc Thinh Ong, Cao Thu Thuy, Le Hong Nga, Nguyen Thi Vy Uyen et autres

In 2022, we established a residual sample serosurveillance program in Ho Chi Minh City, Vietnam. During September 2022-April 2024, we found low measles antibody seroprevalence in children in the city's western region, where a measles outbreak began in May 2024. Serosurveillance could …

Emerging Monkeypox Virus Sublineage C.1 Causing Community Transmission, Vietnam, 2023

Huynh Thi Thuy Hoa, Nguyen Thanh Dung, Le Manh Hung, Nguyen Thi Thu Hong et autres

We studied a community cluster of 25 mpox cases in Vietnam caused by emerging monkeypox virus sublineage C.1 and imported into Vietnam through 2 independent events; 1 major cluster carried a novel APOBEC3-like mutation. Three patients died; all had advanced HIV co-infection. …

A validated cloud-based genomic platform for co-ordinated, expedient global analysis of SARS-CoV-2 genomic epidemiology

Daniel G. Amoako, Nguyen To Anh, Jasmine Bastable, Marc Brouard et autres

Background Viral sequencing has made critical contributions to our understanding of and response to the COVID-19 pandemic, but sequencing capacity and bioinformatic expertise remain limited in many settings. This proof-of-principle study aimed to demonstrate the utility of a cloud-based sequencing analysis pipeline, …

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Spatiotemporal Evolution of SARS-CoV-2 Alpha and Delta Variants during Large Nationwide Outbreak of COVID-19, Vietnam, 2021

Nguyễn Thị Thanh Tâm, Nguyen To Anh, Trinh Son Tung, Phạm Ngọc Thạch et autres

We analyzed 1,303 SARS-CoV-2 whole-genome sequences from Vietnam, and found the Alpha and Delta variants were responsible for a large nationwide outbreak of COVID-19 in 2021. The Delta variant was confined to the AY.57 lineage and caused >1.7 million infections and >32,000 …

Spatiotemporal Evolution of SARS-CoV-2 Alpha and Delta Variants during a Large Nationwide Outbreak in Vietnam, 2021

Nguyễn Thị Thanh Tâm, Nguyen To Anh, Trinh Son Tung, Phạm Ngọc Thạch et autres

ABSTRACT In 2021, Vietnam experienced a large nationwide outbreak of COVID-19, with over 1.7 million infections and 32,000 deaths. We generated 1,303 SARS-CoV-2 whole-genome sequences, and mapped out the public health measures alongside the evolutionary trajectory of the pathogen. The Alpha variant …

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Development and Prospective Evaluation of an Internally Controlled Metagenomic Workflow for Simultaneous Detection of Bacterial and Viral Causes of Central Nervous System Infections

Nghiêm My Ngoc, Nghia Ho Dang Trung, Mai Nguyen Thi Hoang, Nguyen Thi Thu Hong et autres

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Kinetics of Neutralizing Antibodies against Omicron Variant in Vietnamese Healthcare Workers after Primary Immunization with ChAdOx1-S and Booster Immunization with BNT162b2

Nguyen Van Vinh Chau, Lam Anh Nguyet, Nguyen Thanh Dung, Vo Minh Quang et autres

We studied the development and persistence of neutralizing antibodies against SARS-CoV-2 ancestral strain, and Delta and Omicron (BA.1 and BA.2) variants in Vietnamese healthcare workers (HCWs) up to 15 weeks after booster vaccination. We included 47 HCWs, including group 1 (G1, N …

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Kinetics of neutralising antibodies against Omicron variant in Vietnamese healthcare workers after primary immunisation with ChAdOx1-S and booster with BNT162b2

Nguyen Van Vinh Chau, Lam Anh Nguyet, Nguyen Thanh Dung, Vo Minh Quang et autres

Abstract We studied the development and persistence of neutralising antibodies against SARS-CoV-2 ancestral strain, and Delta and Omicron (BA.1 and BA.2) variants in Vietnamese healthcare workers (HCWs) up to 15 weeks after booster vaccination. We included 47 HCWs with different pre-existing immune …

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Immunogenicity of Oxford-AstraZeneca COVID-19 Vaccine in Vietnamese Health-Care Workers

Nguyen Van Vinh Chau, Lam Anh Nguyet, Nguyen Thanh Truong, Le Mau Toan et autres

We studied the immunogenicity of the Oxford-AstraZeneca vaccine in health-care workers of a major infectious diseases hospital in Vietnam. We measured neutralizing antibodies before and 14 days after each dose, and at day 28 and month 3 after dose 1. A total …

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An observational study of breakthrough SARS-CoV-2 Delta variant infections among vaccinated healthcare workers in Vietnam

Nguyen Van Vinh Chau, Nghiêm My Ngoc, Lam Anh Nguyet, Vo Minh Quang et autres

BACKGROUND: Data on breakthrough SARS-CoV-2 Delta variant infections in vaccinated individuals are limited. METHODS: We studied breakthrough infections among Oxford-AstraZeneca vaccinated healthcare workers in an infectious diseases hospital in Vietnam. We collected demographic and clinical data alongside serial PCR testing, measurement of …

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Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam

Nguyễn Văn Vĩnh Châu, Le Nguyen Thanh Nhan, Lam Anh Nguyet, Nguyen Thi Kha Tu et autres

We tested pre-pandemic (2015--2019) plasma samples from 148 Vietnamese children and 100 Vietnamese adults at high risk of zoonotic infections for antibodies against SARS-CoV-2 nucleocapsid and spike proteins. None was positive. The data thus demonstrated no evidence of prior serological cross-reactivity with …

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Absence of SARS-CoV-2 antibodies in pre-pandemic plasma from children and adults in Vietnam

Nguyễn Văn Vĩnh Châu, Le Nguyen Thanh Nhan, Lam Anh Nguyet, Nguyen Thi Kha Tu et autres

Abstract We tested pre-pandemic (2015-2019) plasma samples from 148 Vietnamese children, and 100 Vietnamese adults at high risk of zoonotic infections, for antibodies against SARS-CoV-2 nucleocapsid and spike proteins. None was positive, indicating no prior serological cross-reactivity with SARS-CoV-2 that might explain …

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