Yuqiang Nie

Gram-negative bacteria and endotoxins promote hepatocellular carcinoma progression through the recruitment of myeloid-derived suppressor cells

Yong Zhang, You-Lian Zhou, Xin Nie, Liang‐Jie Zhang et autres

BACKGROUND Bacteria were detected in several human malignancies; however, their presence and biological significance in hepatocellular carcinoma (HCC) remain incompletely characterized. AIM To investigate the role of bacterial components in HCC and to elucidate their effects on the tumor. METHODS Different experimental …

Lactobacillus johnsonii-derived extracellular vesicles restore mucosal immunity via taurine-linked Th17/Treg and IgA/IgG regulation in colitis

Hailan Zhao, Ningning Yue, Yuan Zhang, Cheng‐mei Tian et autres

BACKGROUND: Aberrant mucosal immune responses to gut microbiota contribute to inflammatory bowel disease (IBD), yet the mechanisms linking immunoglobulin-coated bacteria to mucosal inflammation remain unclear. Microbial extracellular vesicles (EVs) have emerged as potential modulators of host–microbiota interactions, metabolism, and immunity. This study …

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Streptococcus gallolyticus supernatant promotes macrophage M2 polarization and regulates the IL-17 pathway in the oncogenesis of colorectal cancer

Jiaqi Wang, Yan Zhang, Jing Xu, Xin Nie et autres

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Clostridium butyricum-induced balance in colonic retinol metabolism and short-chain fatty acid levels inhibit IgA-related mucosal immunity and relieve colitis developments

Jing Xu, Haoming Xu, Xiang Li, Wenqi Huang et autres

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Sa1787: ODORIBACTER. SPLANCHNICUS-INDUCED TRANSFORMATION OF SECONDARY BILE ACIDS MEDIATES THE INHIBITION OF NEUTROPHIL EXTRACELLULAR TRAPS FORMATION IN COLITIS

Jing Xu, Jianhong Li, Haoming Xu, Yao Peng et autres

Odoribacter splanchnicus—A Next-Generation Probiotic Candidate

Jianhong Li, Jing Xu, Guo Xue, Haoming Xu et autres

As an important intestinal microorganism, Odoribacter splanchnicus frequently appears in high-throughput sequencing analyses, although pure culture research on this microorganism is not as advanced. It is widely present in the mammalian gut and is closely associated with the health status of the …

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PPARγ/β/δ Agonists Can Ameliorate Dextran Sodium Sulfate–Induced Colitis and Modulate Gut Microbiota

Jianhong Li, Jing Xu, Jinxia Hu, Haoming Xu et autres

BACKGROUND AND AIM: Peroxisome proliferator-activated receptors (PPARs), as nuclear receptors, modulate both lipid metabolism and inflammatory/immune processes. This study examines the impact of modulating the activities of the PPAR subtypes PPARβ/ð and PPARγ on the gut microbiota in inflammatory bowel disease (IBD). …

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Real-world of Limosilactobacillus reuteri in mitigation of acute experimental colitis

Ningning Yue, Hailan Zhao, Peng Hu, Yuan Zhang et autres

Probiotics have been proposed as a potential strategy for managing ulcerative colitis (UC). However, the underlying mechanisms mediating microbiota-host crosstalk remain largely elusive. Here, we report that Limosilactobacillus reuteri (L. reuteri), as a probiotic, secretes cytoplasmic membrane vesicles (CMVs) that communicate with …

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Houttuynia cordata-Derived Exosome-Like Nanoparticles Mitigate Colitis in Mice via Inhibition of the NLRP3 Signaling Pathway and Modulation of the Gut Microbiota

Jianhong Li, Jing Xu, Chen Huang, Jin-Xia Hu et autres

Background: Plant-derived exosome-like nanoparticles (PELNs) have received widespread attention in treating ulcerative colitis (UC). However, the role of Houttuynia cordata -derived exosome-like nanoparticles (HELNs) in UC remains unclear. This study aims to evaluate the efficacy of HELNs in treating colitis in mice …

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IDDF2024-ABS-0118 Preliminary study on houttuynia cordata-derived exosome-like nanovesicles ameliorating experimental colitis

Jianhong Li, Jing Xu, Haoming Xu, Youlian Zhou et autres

Background Plant-derived exosome-like nanoparticles (PELNs) have been considered to have great prospects in the treatment of ulcerative colitis (UC) as they serve as a natural nano-drug carrier that can improve drug stability and cellular uptake. In this study, we isolated Houttuynia cordata-derived …

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Exploring the diagnostic potential of immunoglobulin A‐microbiota interplay in liver cirrhosis and spontaneous bacterial peritonitis

Liang‐Jie Zhang, Wen‐Qi Huang, Yuan Zhang, Youlian Zhou et autres

The human gut microbiota significantly impacts health, including liver conditions like liver cirrhosis (LC) and spontaneous bacterial peritonitis (SBP). Immunoglobulin A (IgA) plays a central role in maintaining gut microbial balance. Understanding IgA's interplay with gut microbiota and liver health is crucial. …

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EP78 PRELIMINARY STUDY ON HOUTTUYNIA CORDATA-DERIVED EXOSOMELIKE NANOVESICLES AMELIORATING EXPERIMENTAL COLITIS

Jianhong Li, Haoming Xu, Jing Xu, Youlian Zhou et autres