Ron M. Stewart

Multimodal Framework of Left Heart-Pulmonary Vascular Remodeling Underlying Right Ventricular Failure in PH-HFpEF

Farhan Raza, Zachery R. Gregorich, Jack Freeman, Bethany M. Moore et autres

BACKGROUND: Right ventricular (RV) dysfunction in pulmonary hypertension due to heart failure with preserved ejection fraction (PH-HFpEF) leads to adverse outcomes, yet the mechanisms underlying RV failure remain incompletely defined. We aimed to develop a multimodal framework integrating vascular mechanics and myocardial …

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Quantifying Evidence for Competing Biomedical Hypotheses using Large Language Models and Bayesian Analysis

Bethany M. Moore, Jack Freeman, Robert J. Millikin, Chitrasen Mohanty et autres

Science fundamentally depends on the generation and testing of hypotheses, many of them controversial. An explosion in scientific literature has made evaluating hypotheses even within a domain a problem of scale, and risks slowing an already extensive consensus-building process. While this challenge …

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Abstract 1908: Activity of dual BET and CDK9 inhibition in murine models of pancreatic ductal adenocarcinoma.

Michela Cadarso, Austin Stram, Lucas J. Koeppel, Robert J. Millikin et autres

Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) remains a leading cause of cancer related mortality in the U.S. with a 13% 5-year survival rate. Acquired resistance plays a critical role in progression, however targeted therapeutics have been developed for rare molecular subsets. Prior …

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Additional file 1 of SKiM-GPT: combining biomedical literature-based discovery with large language model hypothesis evaluation

Jack Freeman, Robert J. Millikin, L. Xu, Ishaan Sharma et autres

Supporting Information

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Additional file 1 of SKiM-GPT: combining biomedical literature-based discovery with large language model hypothesis evaluation

Jack Freeman, Robert J. Millikin, L. Xu, Ishaan Sharma et autres

Supporting Information

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SKiM-GPT: combining biomedical literature-based discovery with large language model hypothesis evaluation

Jack Freeman, Robert J. Millikin, L. Xu, Ishaan Sharma et autres

Abstract Background Generating and testing hypotheses is a critical aspect of biomedical science. Typically, researchers generate hypotheses by carefully analyzing available information and making logical connections, which are then tested. The accelerating growth of biomedical literature makes it increasingly difficult to keep …

us (code pays fourni par la source)

SKiM-GPT: combining biomedical literature-based discovery with large language model hypothesis evaluation

Jack Freeman, Robert J. Millikin, L. Xu, Ishaan Sharma et autres

Abstract Background Generating and testing hypotheses is a critical aspect of biomedical science. Typically, researchers generate hypotheses by carefully analyzing available information and making logical connections, which are then tested. The accelerating growth of biomedical literature makes it increasingly difficult to keep …

us (code pays fourni par la source)

Additional file 2 of SKiM-GPT: combining biomedical literature-based discovery with large language model hypothesis evaluation

Jack Freeman, Robert J. Millikin, L. Xu, Ishaan Sharma et autres

SKiM_GPT_supplementary_Data

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Additional file 2 of SKiM-GPT: combining biomedical literature-based discovery with large language model hypothesis evaluation

Jack Freeman, Robert J. Millikin, L. Xu, Ishaan Sharma et autres

SKiM_GPT_supplementary_Data

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SKiM-GPT: combining biomedical literature-based discovery with large language model hypothesis evaluation

Jack Freeman, Robert J. Millikin, Liang Xu, Bethany B. Moore et autres

BACKGROUND: Generating and testing hypotheses is a critical aspect of biomedical science. Typically, researchers generate hypotheses by carefully analyzing available information and making logical connections, which are then tested. The accelerating growth of biomedical literature makes it increasingly difficult to keep pace …

us (code pays fourni par la source)

Diminished immune cell adhesion in hypoimmune ICAM-1 knockout human pluripotent stem cells

Sayandeep Saha, W. John Haynes, Jiwon Seo, Natalia M. Del Rio et autres

Gene edited human pluripotent stem cells are a promising platform for developing reparative cellular therapies that evade immune rejection. Existing first-generation hypoimmune strategies have used CRISPR/Cas9 editing to modulate genes associated with adaptive immune responses, but have largely not addressed the innate …

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Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide

Steven V John, Gretchen L. Seim, Billy J Erazo-Flores, James A. Votava et autres

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