Bethan Ogg

Potassium Supplementation and Prevention of Atrial Fibrillation After Cardiac Surgery

Benjamin O’Brien, Niall G. Campbell, Elizabeth J. Allen, Zahra Jamal et autres

IMPORTANCE: Supplementing potassium in an effort to maintain high-normal serum concentrations is a widespread strategy used to prevent atrial fibrillation after cardiac surgery (AFACS), but is not evidence-based, carries risks, and is costly. OBJECTIVE: To determine whether a lower serum potassium concentration …

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Stratified analyses refine association between TLR7 rare variants and severe COVID-19

Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan et autres

Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited.Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and …

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Landiolol and Organ Failure in Patients With Septic Shock

Tony Whitehouse, Md. Anower Hossain, Gavin D. Perkins, Anthony C. Gordon et autres

Importance: Patients with septic shock undergo adrenergic stress, which affects cardiac, immune, inflammatory, and metabolic pathways. β-Blockade may attenuate the adverse effects of catecholamine exposure and has been associated with reduced mortality. Objectives: To assess the efficacy and safety of landiolol in …

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Intravenous Vitamin C for Patients Hospitalized With COVID-19

Simin Aysel Florescu, Dragos Stanciu, Mihaela Florentina Zaharia, Alma Gabriela Kosa et autres

Importance: The efficacy of vitamin C for hospitalized patients with COVID-19 is uncertain. Objective: To determine whether vitamin C improves outcomes for patients with COVID-19. Design, Setting, and Participants: Two prospectively harmonized randomized clinical trials enrolled critically ill patients receiving organ support …

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A second update on mapping the human genetic architecture of COVID-19

Shea J. Andrews, Mattia Cordioli, Christine R. Stevens, Mark J. Daly et autres

Investigating the role of host genetic factors in COVID-19 severity and susceptibility can inform our understanding of the underlying biological mechanisms that influence adverse outcomes and drug development 1 , 2 . Here we present a second updated genome-wide association study (GWAS) …

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Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

In the version of this article initially published, the name of Ana Margarita Baldión-Elorza, of the SCOURGE Consortium, appeared incorrectly (as Ana María Baldion) and has now been amended in the HTML and PDF versions of the article.

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GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo‐Castineira, Konrad Rawlik, Andrew D. Bretherick, Ting Qi et autres

Abstract Critical illness in COVID-19 is an extreme and clinically homogeneous disease phenotype that we have previously shown 1 to be highly efficient for discovery of genetic associations 2 . Despite the advanced stage of illness at presentation, we have shown that …

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Effect of Angiotensin-Converting Enzyme Inhibitor and Angiotensin Receptor Blocker Initiation on Organ Support–Free Days in Patients Hospitalized With COVID-19

Simin Aysel Florescu, Dragos Stanciu, Mihaela Florentina Zaharia, Alma Gabriela Kosa et autres

IMPORTANCE: Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective: To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS: …

Correction: Impact of renal-replacement therapy strategies on outcomes for patients with chronic kidney disease: a secondary analysis of the STARRT-AKI trial

Ary Serpa Neto, Orla M. Smith, M. Lynn Weir, Haibo Qiu et autres

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Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial

Simin Florescu, Delia Stanciu, Mihaela Florentina Zaharia, Alma Kosa et autres

Importance: The longer-term effects of therapies for the treatment of critically ill patients with COVID-19 are unknown. Objective: To determine the effect of multiple interventions for critically ill adults with COVID-19 on longer-term outcomes. Design, Setting, and Participants: Prespecified secondary analysis of …

Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19

Simin Florescu, Delia Stanciu, Mihaela Florentina Zaharia, Alma Kosa et autres

Importance: The efficacy of antiplatelet therapy in critically ill patients with COVID-19 is uncertain. Objective: To determine whether antiplatelet therapy improves outcomes for critically ill adults with COVID-19. Design, Setting, and Participants: In an ongoing adaptive platform trial (REMAP-CAP) testing multiple interventions …

Whole-genome sequencing reveals host factors underlying critical COVID-19

Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, Alex Stuckey et autres

after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically …

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