Katherine E. Miller

Publisher Correction: Adjuvant personalized multivalent neoantigen DNA vaccination for MGMT unmethylated glioblastoma: a phase 1 trial

Elizabeth A.R. Garfinkle, Renzo Perales‐Linares, Ryan C. Gimple, Alexandra J. Livingstone et autres

In the version of the article initially published, in the top-left graph of Fig. 3b, the y -axis label was “CD4 + CD69 + (%, delta)” but should have been “CD8 + CD69 + (%, delta)”. In the top-right box of Fig. …

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Supplementary Figure S2 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplementary Fig. S2. A) UMAP visualization of lymphoid marker genes. B) Relative proportions of lymphoid clusters per patient per timepoint per metastasis site. C) Relative proportions of lymphoid clusters per patient per timepoint per response group.

Supplementary Figure S6 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplementary Fig. S6. A) UMAP visualization of myeloid cell type markers for macrophages (CD68), M2-like macrophages (CD163), antigen-presenting cells (HLA-DRA), monocytes (CD14), dendritic cells (CD1C), and mast cells (KIT). B) Relative proportions of myeloid clusters per patient per timepoint per metastasis site. …

Supplementary Figure S7 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplementary Fig. S7. A) UMAP visualization of G1/S CDKs, CDK4, CDK6, and CDK2. B) C) Heatmap depicting differential expression of CDK4/6 target genes and proliferation markers in each cluster grouped by response. Color indicates average log2FC where a positive value indicates the …

Data from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Abstract Purpose: In advanced estrogen receptor (ER)–positive/human epidermal growth factor receptor 2 (HER2)–negative breast cancer, the combination of cyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) with endocrine therapy (ET) is the standard of care for treatment in the first-line setting. Although CDK4/6is …

Supplementary Figure S3 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplementary Fig. S3. A) UMAP visualization of G1/S CDKs, CDK4, CDK6, and CDK2. B) C) Heatmap depicting differential expression of CDK4/6 target genes and proliferation markers in each cluster grouped by response. Color indicates average log2FC where a positive value indicates the …

Supplementary Figure S1 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplementary Fig. S1. A) UMAP visualization of scRNA-seq data colored by patient identity. B) UMAP visualization of scRNA-seq data colored by timepoint (T1 = pre-abemaciclib and ET, T2 = post-abemaciclib and ET). C) Dot plot of proportion of copy number variation (CNV) …

Supplementary Tables S2-S12 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplementary Table S2. Patient characteristics and number of cells analyzed. Supplementary Table S3. Marker genes for each cluster Supplementary Table S4. ANOVA with Tukey HSD multiple test correction results for cell type population size comparisons between response groups. Supplementary Table S5. ANOVA …

Supplementary Figure S10 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplemental Figure 10. Kaplan-Meier plots showing association of (A) myeloid cluster gene signatures and (B) relative cell type deconvolution fraction with survival in metastatic patients in the AURORA (n = 34 patients) and NCT03401359 dataset (n = 64 patients).

Supplementary Figure S8 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplementary Fig. S8. Heatmap depicting gene set enrichment results identified from genes that were differentially expressed between T1 and T2 for each myeloid cluster in each response group. Color indicates normalized enrichment score where a positive value indicates the pathway was more …

Supplementary Figure S9 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplementary Fig. S9. A) Heatmap of top 20 differentially expressed genes between myeloid cluster 0: APOC1 TAMs, myeloid cluster 5: TREM2 TAMs, and cluster 7: APOC2 TAMs. B) Heatmap of top 20 enriched pathways derived from genes identified as differentially expressed between …

Supplementary Table S1 from Single-Cell Transcriptomics Reveals Immune Landscape Dynamics in Metastatic Hormone Receptor–Positive Breast Cancer Treated with Abemaciclib and Endocrine Therapy

Corinne Haines, Binita Chakraborty, Daniel Michaud, Ching‐yi Chang et autres

Supplementary Table S1. Representativeness of Study Participants.