Profil bibliographique

Hilary J. Lewis

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

93Publications signalées

1310Citations signalées

1Affiliations récentes

Les institutions déclarées

AstraZeneca (United Kingdom)

Les domaines associés

Lung Cancer Treatments and MutationsHER2/EGFR in Cancer ResearchEstrogen and related hormone effectsAdvanced Breast Cancer TherapiesFibroblast Growth Factor Research

Les publications récentes

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 6 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

Human PK simulation after a single dose of compounds 1 and 2 over 24h

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Results from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

Supplementary to results and discussion

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S2 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

Mass Spectrometer and UPLC system parameters for in vivo PK analysis.

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S4 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

Kinetic analysis of covalent inhibition of EGFR Exon20 NPGIns.

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S7 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

EGFR peptide ion isolation list, SILAC experiment 2

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S11 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

Optimised transitions from the Waters TQ-XS for compound 1, compound 4, compound 3, compound 2, and clozapine (internal standard) utilising the M+H ion

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 2 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

Additional data supporting experimental findings on media stability of compounds 1-4

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S14 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

Half-lives obtained from fitting to SILAC data

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 7 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

Kinetics of compounds 1-4 in NCI-H2073SVD cells media

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 10 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

PD model simulations against observed data after a single dose compound 4 (testing slower kinact than the in vitro measurement)

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Table S8 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

EGFR peptide multiple reaction monitoring transitions, SILAC experiment 3

0 citations

Accès ouvert 2026 supplementary-materials OpenAlex

Supplementary Figure 1 from Preclinical to Clinical Translation of Pharmacokinetic–Pharmacodynamic Relationship in EGFR Exon20Ins Mutations: A Modeling Framework for Irreversible Inhibitors

Adriana Savoca, Diana Zindel, Radosław Polański, Demetrios H. Kostomiris et autres

Chemical structures for compounds 1-4

0 citations

Profil ORCID Notice OpenAlex

BNTIC News n’est pas le producteur de ces données. Les publications sont interrogées à la demande dans Crossref, OpenAIRE, DOAJ, Europe PMC, HAL, DataCite, AfricArXiv, ROR et la Banque mondiale, sans clé d’accès. OpenAlex reste optionnel. Aucun service payant n’est nécessaire et aucune donnée externe n’est enregistrée en base. Consulter les sources et leurs limites.