Alexander Guðjónsson

A young child formula with Limosilactobacillus reuteri and GOS modulates gut microbiome and enhances bone and muscle development: a randomized trial

Nicolas Bonnet, Maria Rosario Capeding, Léa Siegwald, Marc Garcia‐Garcerà et autres

In this randomized, double-blind controlled trial, 182 Filipino children aged 2-3 years received either an experimental young child formula (EYCF) containing a combination of Limosilactobacillus reuteri DSM 17938 and galacto-oligosaccharides (GOS; n = 91) or a minimally fortified milk (CM; n = …

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Integrating GWAS meta-analysis with human brain cell mapping implicates the amygdala and the midbrain in the pathogenesis of tinnitus

Nick M. A. Schubert, Shuyang Yao, Maryam Kazemi Naeini, Natalia Trpchevska et autres

Tinnitus is a distressing condition affecting millions of people worldwide, yet treatment options remain very limited. Molecular evidence on the cellular origins of tinnitus in humans is lacking. Here, we performed a genome-wide association meta-analysis of clinically diagnosed and self-reported tinnitus on …

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A YOUNG CHILD FORMULA SUPPLEMENTED WITH L. REUTERI AND GALACTO-OLIGOSACCHARIDES MODULATES THE COMPOSITION AND FUNCTION OF THE GUT MICROBIOME SUPPORTING BONE AND MUSCLE DEVELOPMENT IN TODDLERS

Nicolas Bonnet, Maria Rosario Capeding, Léa Siegwald, Marc Garcia‐Garcerà et autres

Abstract Key Points This section will be completed further Importance Toddlerhood is a key window of opportunity for development of musculoskeletal system and microbiome. In this study we tested the efficacy of a synbiotic-based young child formula on bone and muscle strength …

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Author Correction: Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease

Elisabet Alexandra Frick, Valur Emilsson, Þórarinn Jónmundsson, Anna E. Steindorsdottir et autres

In the version of this article initially published, in Fig. 4a, the blue data points were presented as odds ratios in the same panels and on the same scale as the yellow data points (hazard ratios), which was incorrect. The blue data …

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Serum proteomics reveal APOE-ε4-dependent and APOE-ε4-independent protein signatures in Alzheimer’s disease

Elisabet Alexandra Frick, Valur Emilsson, Þórarinn Jónmundsson, Anna E. Steindorsdottir et autres

A deeper understanding of the molecular processes underlying late-onset Alzheimer’s disease (LOAD) could aid in biomarker and drug target discovery. Using high-throughput serum proteomics in the prospective population-based Age, Gene/Environment Susceptibility–Reykjavik Study (AGES) cohort of 5,127 older Icelandic adults (mean age, 76.6 …

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Genome-wide association meta-analysis identifies 48 risk variants and highlights the role of the stria vascularis in hearing loss

Yuguang Gao, L. C. M., André Goedegebure, Antti A. Mäkitie et autres

Hearing loss is one of the top contributors to years lived with disability and is a risk factor for dementia. Molecular evidence on the cellular origins of hearing loss in humans is growing. Here, we performed a genome-wide association meta-analysis of clinically …

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Genetic Complexities of Cerebral Small Vessel Disease, Blood Pressure, and Dementia

Muralidharan Sargurupremraj, Aïcha Soumaré, Joshua C. Bis, Ida L. Surakka et autres

Importance: Vascular disease is a treatable contributor to dementia risk, but the role of specific markers remains unclear, making prevention strategies uncertain. Objective: To investigate the causal association between white matter hyperintensity (WMH) burden, clinical stroke, blood pressure (BP), and dementia risk, …

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Gut microbiota composition is altered in postural orthostatic tachycardia syndrome and post-acute COVID-19 syndrome

Viktor Hamrefors, Fredrik Kahn, Madlene Holmqvist, Katherine B Carlson et autres

Postural Orthostatic Tachycardia Syndrome (POTS) reflects an autonomic dysfunction, which can occur as a complication to COVID-19. Our aim was to examine gastrointestinal symptoms and gut microbiota composition in patients with POTS and post-acute COVID-19 syndrome (PACS), compared with controls. POTS patients …

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Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer’s disease

Valborg Guðmundsdóttir, Elisabet Alexandra Frick, Valur Emilsson, Þórarinn Jónmundsson et autres

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Serum proteomics reveals APOE dependent and independent protein signatures in Alzheimer’s disease

Elisabet Alexandra Frick, Valur Emilsson, Þórarinn Jónmundsson, Anna E. Steindorsdottir et autres

Summary The current demand for early intervention, prevention, and treatment of late onset Alzheimer’s disease (LOAD) warrants deeper understanding of the underlying molecular processes which could contribute to biomarker and drug target discovery. Utilizing high-throughput proteomic measurements in serum from a prospective …

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Complexities of cerebral small vessel disease, blood pressure, and dementia relationship: new insights from genetics

Muralidharan Sargurupremraj, Aïcha Soumaré, Joshua C. Bis, Ida L. Surakka et autres

Abstract Importance There is increasing recognition that vascular disease, which can be treated, is a key contributor to dementia risk. However, the contribution of specific markers of vascular disease is unclear and, as a consequence, optimal prevention strategies remain unclear. Objective To …

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Genetic insights of all‐cause and vascular dementia through genome‐wide association studies

Bernard Fongang, Muralidharan Sargurupremraj, Xueqiu Jian, Aniket Mishra et autres

Abstract Background Genome‐wide association studies (GWAS) have identified more than 40 genetic loci associated with Alzheimer’s disease (AD). Although vascular dementia (VaD) is the second most common type of dementia after AD, the genetic contribution to VaD is understudied. We hypothesize that …

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