Accès ouvert
2025
article
OpenAlex
Payal Pratap, Christopher A. Cottrell, James C. Quinn, Diane G. Carnathan et autres
During infection, the fusion peptide (FP) of HIV envelope glycoprotein (Env) serves a central role in viral fusion with the host cell. As such, the FP is highly conserved and therefore an attractive epitope for vaccine design. Here, we describe a vaccination …
us, gb
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Parham Ramezani-Rad, Christopher A. Cottrell, Ester Marina-Zárate, Alessia Liguori et autres
A protective vaccine against human immunodeficiency virus (HIV) will likely need to induce broadly neutralizing antibodies (bnAbs) that engage relatively conserved epitopes on the HIV envelope glycoprotein (Env) trimer. Nearly all vaccine strategies to induce bnAbs require the use of complex immunization …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Parham Ramezani-Rad, Christopher A. Cottrell, Ester Marina-Zárate, Alessia Liguori et autres
A protective vaccine against HIV will likely need to induce broadly neutralizing antibodies (bnAbs) that engage relatively conserved epitopes on the HIV envelope glycoprotein (Env) trimer. Nearly all vaccine strategies to induce bnAbs require the use of relatively complex immunization regimens involving …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Payal Pratap, Christopher A. Cottrell, James C. Quinn, Diane G. Carnathan et autres
During infection, the fusion peptide (FP) of HIV envelope glycoprotein (Env) serves a central role in viral fusion with the host cell. As such, the FP is highly conserved and therefore an attractive epitope for vaccine design. Here, we describe a vaccination …
us, gb
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Sedem Dankwa, Christina Kosman, Maria Dennis, Elena E. Giorgi et autres
To eliminate vertical HIV transmission and achieve therapy-free viral suppression among children living with HIV, novel strategies beyond antiretroviral therapy (ART) are necessary. Our group previously identified a triple broadly neutralizing antibody (bNAb) combination comprising of 3BNC117, PGDM1400 and PGT151 that mediates …
us
(code pays fourni par la source)
2024
article
OpenAlex
Zeynep Bahadır, Ioanna Pahountis, Kenneth Vuong, Christina Kosman et autres
Abstract Background In 2022, UNAIDS estimated out of the 1.7 million children living with HIV, only 57.1% had access to antiretroviral therapy (ART). Though ART has significantly decreased HIV-associated morbidity and mortality, it cannot eliminate the latent viral reservoir. Consequently, most people …
us
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Christopher A. Cottrell, Payal Pratap, Kimberly M. Cirelli, Diane G. Carnathan et autres
Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the development of an effective HIV vaccine. Rational protein vaccine design and non-conventional …
us, gb
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Sedem Dankwa, Christina Kosman, Maria Dennis, Elena E. Giorgi et autres
ABSTRACT To eliminate vertical HIV transmission and achieve therapy-free viral suppression among children living with HIV, novel strategies beyond antiretroviral therapy (ART) are necessary. Our group previously identified a triple bNAb combination comprising of 3BNC117, PGDM1400 and PGT151 that mediates robust in …
us
(code pays fourni par la source)
Accès ouvert
2023
preprint
OpenAlex
Christopher A. Cottrell, Payal Pratap, Kimberly M. Cirelli, Diane G. Carnathan et autres
Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the development of an effective HIV vaccine. Rational protein vaccine design and non-conventional …
us, gb, Afrique du Sud
(code pays fourni par la source)
Accès ouvert
2022
article
OpenAlex
Aleksandar Antanasijevic, Charles A. Bowman, Robert N. Kirchdoerfer, Christopher A. Cottrell et autres
One of the rate-limiting steps in analyzing immune responses to vaccines or infections is the isolation and characterization of monoclonal antibodies. Here, we present a hybrid structural and bioinformatic approach to directly assign the heavy and light chains, identify complementarity-determining regions, and …
us
(code pays fourni par la source)
Accès ouvert
2021
article
OpenAlex
Murillo Silva, Yu Kato, Mariane B. Melo, Ivy Phung et autres
, and HIV tier 2 neutralizing antibodies in nonhuman primates. Together, these findings shed new light on mechanisms by which saponin adjuvants act to promote the immune response and suggest that SMNP may be a promising adjuvant in the setting of HIV, …
us
(code pays fourni par la source)
Accès ouvert
2021
preprint
OpenAlex
Aleksandar Antanasijevic, Charles A. Bowman, Robert N. Kirchdoerfer, Christopher A. Cottrell et autres
Abstract One of the rate-limiting steps in analyzing immune responses to vaccines or infections is the isolation and characterization of monoclonal antibodies. Here, we present a hybrid structural and bioinformatic approach to directly assign the heavy and light chains, identify complementarity-determining regions …
us
(code pays fourni par la source)