Discovery, characterisation and optimisation of bicyclic peptide inhibitors that disarm Staphylococcus aureus α-hemolysin
Jonathan R Whiteside, Nick Lewis, L. Diaz Saez, Hector Newman et autres
0 citationsbioRxiv (Cold Spring Harbor Laboratory)
Paul Beswick
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77Publications signalées
1764Citations signalées
2Affiliations récentes
Institutions déclarées
Domaines associés
Toxin Mechanisms and ImmunotoxinsMonoclonal and Polyclonal Antibodies ResearchAdenosine and Purinergic SignalingPolyamine Metabolism and ApplicationsSynthesis and Biological Evaluation
Publications récentes
Utilizing Constrained Bicyclic Peptides for In Vitro Diagnostics
André Shamsabadi, Adam Creamer, Chris Sadler, Aida Abdelwahed et autres
0 citationsACS Nano
High-Throughput Identification and Characterization of LptDE-Binding Bicycle Peptides Using Phage Display and Cryo-EM
Shenaz Allyjaun, Steven W. Hardwick, Simone Newell, Finn P. Holding et autres
2 citationsJournal of Medicinal Chemistry
Investigation of anti-SARS CoV-2 multimeric bicyclic peptide inhibitors in a range of pre-clinical therapeutic settings
Maximilian A. J. Harman, Katherine U. Gaynor, Guido Papa, Simone Pellegrino et autres
0 citationsbioRxiv (Cold Spring Harbor Laboratory)
Discovery and chemical optimisation of a potent, Bi-cyclic antimicrobial inhibitor of Escherichia coli PBP3
Catherine E Rowland, Hector Newman, Tazmin T. Martin, Rachel Dods et autres
8 citationsCommunications Biology
Conjugation to a transferrin receptor 1-binding Bicycle peptide enhances ASO and siRNA potency in skeletal and cardiac muscles
Michael E. Østergaard, Michele Carrer, Brooke A. Anderson, Megan Afetian et autres
22 citationsNucleic Acids Research
Investigating Penetration and Antimicrobial Activity of Vector-Bicycle Conjugates
Andreas Hadjicharalambous, Hector Newman, Nick Lewis, Catherine E Rowland et autres
3 citationsACS Infectious Diseases
Abstract 5807: Bicycle Toxin Conjugates®for the treatment of solid tumors
Stephen J. Walsh, Johanna Lahdenranta, Philip Huxley, Gemma Mudd et autres
2 citationsCancer Research
Discovery and chemical optimisation of a Potent, Bi-cyclic (Bicycle ® ) Antimicrobial Inhibitor of Escherichia coli PBP3
Catherine E Rowland, Hector Newman, Tazmin T. Martin, Rachel Dods et autres
1 citationbioRxiv (Cold Spring Harbor Laboratory)
CCDC 2175257: Experimental Crystal Structure Determination
Gemma Mudd, Steven J. Stanway, David R. Witty, Alex Thomas et autres
0 citationsThe Cambridge Structural Database
Structure-Guided Chemical Optimization of Bicyclic Peptide (Bicycle) Inhibitors of Angiotensin-Converting Enzyme 2
Maximilian A. J. Harman, Steven J. Stanway, Heather S. Scott, Yuliya Demydchuk et autres
12 citationsJournal of Medicinal Chemistry
Multivalent bicyclic peptides are an effective antiviral modality that can potently inhibit SARS-CoV-2
Katherine U. Gaynor, Marina Vaysburd, Maximilian A. J. Harman, Anna Albecka et autres
26 citationsNature Communications
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