Lynda Hayashi

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease

Ricardo Melo Ferreira, Debora L. Gisch, Carrie L. Phillips, Ying‐Hua Cheng et autres

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An atlas of healthy and injured cell states and niches in the human kidney

Blue B. Lake, Rajasree Menon, Seth Winfree, Qiwen Hu et autres

. Here we applied multiple single-cell and single-nucleus assays (>400,000 nuclei or cells) and spatial imaging technologies to a broad spectrum of healthy reference kidneys (45 donors) and diseased kidneys (48 patients). This has provided a high-resolution cellular atlas of 51 main …

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Multi-Scalar Data Integration Links Glomerular Angiopoietin-Tie Signaling Pathway Activation With Progression of Diabetic Kidney Disease

Jiahao Liu, Viji Nair, Yiyang Zhao, Dong‐Yuan Chang et autres

Diabetic kidney disease (DKD) is the leading cause of end-stage kidney disease (ESKD). Prognostic biomarkers reflective of underlying molecular mechanisms are critically needed for effective management of DKD. A three-marker panel was derived from a proteomics analysis of plasma samples by an …

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A user-friendly tool for cloud-based whole slide image segmentation with examples from renal histopathology

Brendon Lutnick, David Manthey, Jan U. Becker, Brandon Ginley et autres

Background: Image-based machine learning tools hold great promise for clinical applications in pathology research. However, the ideal end-users of these computational tools (e.g., pathologists and biological scientists) often lack the programming experience required for the setup and use of these tools which …

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Integrated single-cell sequencing and histopathological analyses reveal diverse injury and repair responses in a participant with acute kidney injury: a clinical-molecular-pathologic correlation

Rajasree Menon, Andrew S. Bomback, Blue B. Lake, Christy Stutzke et autres

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A Participant-Centered Approach to Understanding Risks and Benefits of Participation in Research Informed by the Kidney Precision Medicine Project

Catherine R. Butler, Paul S. Appelbaum, Heather Ascani, Mark P. Aulisio et autres

An understanding of the ethical underpinnings of human subjects research that involves some risk to participants without anticipated direct clinical benefit-such as the kidney biopsy procedure as part of the Kidney Precision Medicine Project (KPMP)-requires a critical examination of the risks as …

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Cadherin-11, Sparc-related modular calcium binding protein-2, and Pigment epithelium-derived factor are promising non-invasive biomarkers of kidney fibrosis

Insa M. Schmidt, Mia R. Colona, Bryan Kestenbaum, Leonidas G. Alexopoulos et autres

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Patient perspectives and involvement in precision medicine research

Katherine R. Tuttle, K Tuttle, Jack Bebiak, Keith Brown et autres

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Rationale and design of the Kidney Precision Medicine Project

Ian H. de Boer, Ian H. de Boer, Alpers Ce, Evren U. Azeloglu et autres

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Large-scale, three-dimensional tissue cytometry of the human kidney: a complete and accessible pipeline

Michael J. Ferkowicz, Seth Winfree, Angela R. Sabo, Malgorzata M. Kamocka et autres

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