Gijsbert A. van der Marel

Long, Synthetic Staphylococcus aureus Type 8 Capsular Oligosaccharides Reveal Structural Epitopes for Effective Immune Recognition

Kitt Emilie Østerlid, Charlotte Sorieul, Luca Unione, Sizhe Li et autres

High Resolution Image Download MS PowerPoint Slide Staphylococcus aureus is a Gram-positive bacterium that is responsible for severe nosocomial infections. The rise of multidrug-resistant strains, which can pose significant health threats, prompts the development of new treatment interventions, and much attention has …

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PGL-III, a Rare Intermediate of Mycobacterium leprae Phenolic Glycolipid Biosynthesis, Is a Potent Mincle Ligand

Shigenari Ishizuka, J. Hessel M. van Dijk, Tomomi Kawakita, Yuji Miyamoto et autres

High Resolution Image Download MS PowerPoint Slide Although leprosy (Hansen’s disease) is one of the oldest known diseases, the pathogenicity of Mycobacterium leprae ( M. leprae ) remains enigmatic. Indeed, the cell wall components responsible for the immune response against M. leprae …

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4-Thioribose Analogues of Adenosine Diphosphate Ribose (ADPr) Peptides

Jerre M. Madern, Jim Voorneveld, J.G.M. Rack, Hans A. V. Kistemaker et autres

Adenosine diphosphate (ADP) ribosylation is an important post-translational modification (PTM) that plays a role in a wide variety of cellular processes. To study the enzymes responsible for the establishment, recognition, and removal of this PTM, stable analogues are invaluable tools. We describe …

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Total Synthesis and Structural Studies of Zwitterionic Bacteroides fragilis Polysaccharide A1 Fragments

Zhen Wang, Ana M. Poveda, Qingju Zhang, Luca Unione et autres

High Resolution Image Download MS PowerPoint Slide Zwitterionic polysaccharides (ZPSs) are exceptional carbohydrates, carrying both positively charged amine groups and negatively charged carboxylates, that can be loaded onto MHC-II molecules to activate T cells. It remains enigmatic, however, how these polysaccharides bind …

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Supplementary Figure 2 from Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand–Peptide Conjugates

Gijs G. Zom, Selina Khan, Cedrik Michael Britten, Vinod Sommandas et autres

PDF file - 679K, Supplementary figure 2. In vitro T-cell activation induced by conjugated SLP.

Data from Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand–Peptide Conjugates

Gijs G. Zom, Selina Khan, Cedrik Michael Britten, Vinod Sommandas et autres

Abstract Chemical conjugates comprising synthetic Toll-like receptor ligands (TLR-L) covalently bound to antigenic synthetic long peptides (SLP) are attractive vaccine modalities, which can induce robust CD8+ T-cell immune responses. Previously, we have shown that the mechanism underlying the power of TLR-L SLP …

Supplementary Figure Legends from Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand–Peptide Conjugates

Gijs G. Zom, Selina Khan, Cedrik Michael Britten, Vinod Sommandas et autres

PDF file - 89K

Supplementary Figure 1 from Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand–Peptide Conjugates

Gijs G. Zom, Selina Khan, Cedrik Michael Britten, Vinod Sommandas et autres

PDF file - 266K, Supplementary figure 1. DC maturation by TLR2-L SLP conjugates.

Data from Efficient Induction of Antitumor Immunity by Synthetic Toll-like Receptor Ligand–Peptide Conjugates

Gijs G. Zom, Selina Khan, Cedrik Michael Britten, Vinod Sommandas et autres

Abstract Chemical conjugates comprising synthetic Toll-like receptor ligands (TLR-L) covalently bound to antigenic synthetic long peptides (SLP) are attractive vaccine modalities, which can induce robust CD8+ T-cell immune responses. Previously, we have shown that the mechanism underlying the power of TLR-L SLP …

The development of a broad-spectrum retaining β-exo-galactosidase activity-based probe

C.J. Kuo, Qin Su, Adrianus M. C. H. van den Nieuwendijk, Thomas J. M. Beenakker et autres

Acid β-galactosidase (GLB1) and galactocerebrosidase (GALC) are retaining exo-β-galactosidases involved in lysosomal glycoconjugate metabolism. Deficiency of GLB1 may result in the lysosomal storage disorders GM1 gangliosidosis, Morquio B syndrome, and galactosialidosis, and deficiency of GALC may result in Krabbe disease. Activity-based protein …

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Trans -cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 α- d -mannosidases through a bump–hole strategy

Alexandra Males, Ken Kok, Alba Nin‐Hill, Nicky de Koster et autres

1,6- Trans -manno-cyclosulfamidate 6 inhibits selectively an L310S mutant of Caulobacter GH47 α- d -mannosidase by virtue of its 1 C 4 conformation and bump-and-hole strategy, enabling allele-specific inhibition within the GH47 α-mannosidase family.

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Synthetic Zwitterionic Streptococcus pneumoniae Type 1 Oligosaccharides Carrying Labile O‐Acetyl Esters

Zhen Wang, Ana Gimeno, Marta G. Lete, Herman S. Overkleeft et autres

Abstract We herein report the first total synthesis of the Streptococcus pneumoniae serotype 1 (Sp1) oligosaccharide, a unique zwitterionic capsular polysaccharide carrying labile O‐acetyl esters. The target oligosaccharides, featuring rare α‐2,4‐diamino‐2,4,6‐trideoxy galactose (AAT) and α‐galacturonic acids, were assembled up to the 9‐mer …

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