Miodrag Ognjanovic

Prognostic value of circulating proteins at diagnosis among patients with lung cancer: a comprehensive analysis by smoking status

Xiaoshuang Feng, Hilary A. Robbins, Anush Mukeriya, Lenka Foretová et autres

Background: Improved prediction of prognosis among lung cancer patients could facilitate better clinical management. We aimed to study the prognostic significance of circulating proteins at the time of lung cancer diagnosis, among patients with and without smoking history. Methods: We measured 91 …

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Abstract LB134: Mutational signatures in colorectal cancer from 11 countries reveal new insights in early-onset colorectal cancer

Wellington dos Santos, Marcos Díaz‐Gay, Sarah Moody, S. Senkin et autres

Abstract Background: Colorectal cancers (CRC) have an important impact on both incidence and mortality worldwide, with varying rates in different parts of the world. Despite an overall decrease in incidence in the past years, an alarming increase in early onset colorectal cancer …

fr, us, gb, ca, th, br, cz, ar, pl, co (code pays fourni par la source)

The Mutographs biorepository: A unique genomic resource to study cancer around the world

Sandra Pérdomo, Behnoush Abedi‐Ardekani, Ana Carolina de Carvalho, Aida Ferreiro-Iglesias et autres

Large-scale biorepositories and databases are essential to generate equitable, effective, and sustainable advances in cancer prevention, early detection, cancer therapy, cancer care, and surveillance. The Mutographs project has created a large genomic dataset and biorepository of over 7,800 cancer cases from 30 …

fr, us, br, it, th, ca, Malawi, sk, gb, cz, co, lt, bg, hr, gr, hu, pl, ir, Kenya, in, Tanzanie, ch, ro, ua, ar, ru, sg, nl (code pays fourni par la source)

Survival and prognostic factors of early‐stage non‐small cell lung cancer in Central and Eastern Europe: A prospective cohort study

Mahdi Sheikh, Shama Virani, Hilary A. Robbins, Lenka Foretová et autres

BACKGROUND: Although early diagnosis and surgical resection of the tumor have been shown to be the most important predictors of lung cancer survival, long-term survival for surgically-resected early-stage lung cancer remains poor. AIMS: In this prospective study we aimed to investigate the …

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Genetic Analysis of Lung Cancer and the Germline Impact on Somatic Mutation Burden

Aurélie AG Gabriel, Joshua Atkins, Ricardo Cortez Cardoso Penha, Karl Smith-Byrne et autres

BACKGROUND: Germline genetic variation contributes to lung cancer (LC) susceptibility. Previous genome-wide association studies (GWAS) have implicated susceptibility loci involved in smoking behaviors and DNA repair genes, but further work is required to identify susceptibility variants. METHODS: To identify LC susceptibility loci, …

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Is hypermethylation of SOX1 gene an independent prognostic marker in surgically resected non-small cell lung cancer?

Milica Kontić, Dragana J. Jovanović, Izidor Kern, Heather H. Nelson et autres

Background: Promoter hypermethylation of tumor suppressor genes presents promising markers for lung cancer diagnosis and prognosis. The purpose of this study was to determine the association between the promoter hypermethylation of multiple genes and 5-year survival rate in patients with Non-small cell …

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Genetic analysis of lung cancer reveals novel susceptibility loci and germline impact on somatic mutation burden

Aurélie AG Gabriel, Joshua Atkins, Ricardo Cortez Cardoso Penha, Karl Smith-Byrne et autres

ABSTRACT Germline genetic variants are involved in lung cancer (LC) susceptibility. Previous genome-wide association studies (GWAS) have implicated genes involved in smoking propensity and DNA repair but further work is required to identify additional LC susceptibility variants and to investigate LC disease …

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Morphological findings in frozen non-neoplastic kidney tissues of patients with kidney cancer from large-scale multicentric studies on renal cancer

Behnoush Abedi‐Ardekani, Dariush Nasrollahzadeh, Lars Egevad, Rosamonde E. Banks et autres

There are unexplained geographical variations in the incidence of kidney cancer with the high rates reported in Baltic countries, as well as eastern and central Europe. Having access to a large and well-annotated collection of "tumor/non-tumor" pairs of kidney cancer patients from …

fr, ir, se, gb, cz, ro, lv, ca (code pays fourni par la source)

Morphological findings in frozen non-neoplastic kidney tissues of patients with kidney cancer from large-scale multicentric studies on genomics of renal cancer

Behnoush Abedi‐Ardekani, Dariush Nasrollahzadeh, Lars Egevad, Rosamonde E. Banks et autres

Abstract Background There are unexplained geographical variations in the incidence of kidney cancer with the high rates reported in Baltic countries, as well as eastern and central Europe. Analysis of non-neoplastic tissues is a way to better understand the carcinogenesis. Methods Having …

fr, se, gb, cz, ro, lv, ca (code pays fourni par la source)

Fine mapping of MHC region in lung cancer highlights independent susceptibility loci by ethnicity

Aida Ferreiro-Iglesias, Corina Lesseur, James McKay, Younghun Han et autres

Lung cancer has several genetic associations identified within the major histocompatibility complex (MHC); although the basis for these associations remains elusive. Here, we analyze MHC genetic variation among 26,044 lung cancer patients and 20,836 controls densely genotyped across the MHC, using the …

fr, ca, us, se, ru, rs, pl, cz, ro, dk, es, il, de, at, cn, gb, nl, kr, no (code pays fourni par la source)

Corrigendum re “Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma” [Eur Urol 2017;72:747–54]

Mitchell J. Machiela, Jonathan N. Hofmann, Robert Carreras‐Torres, Kevin M. Brown et autres

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Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma (vol 72, pg 747, 2017)

Mitchell J. Machiela, Jonathan N. Hofmann, Robert Carreras‐Torres, Kevin M. Brown et autres