Yury Valdés-Balbín

Safety and Cross-Neutralizing Immunity Against SARS-CoV-2 Omicron Sub-Variant After a Booster Dose with SOBERANA® Plus in Children and Adolescents

Dagmar García-Rivera, Meiby Rodríguez-González, Beatriz Paredes-Moreno, Rinaldo Puga-Gómez et autres

Background: With the emergence of SARS-CoV-2 Omicron sub-variants exhibiting increased transmissibility and immune escape, booster immunization is recommended. Ideally, vaccination across all age groups, including children and adolescents, is critical to control viral spread and reduce variant emergence. The heterologous scheme consisting …

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Safety and Cross‐Reactive Immunity Against SARS‐CoV‐2 Omicron Sub‐Variant After a Booster Dose with SOBERANA ® Plus in Children and Adolescents

Dagmar García-Rivera, Meiby Rodríguez-González, Beatriz Paredes-Moreno, Rinaldo Puga-Gómez et autres

Background: With the emergence of SARS-CoV-2 Omicron sub-variants exhibiting in-creased transmissibility and immune escape, booster immunization is recommended. Ideally, vaccination across all age groups, including children and adolescents, is critical to control viral spread and reduce variant emergence. The heterologous three-dose regimen …

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LC‐MS/MS Characterization of SOBERANA 02, a Receptor Binding Domain‐Tetanus Toxoid Conjugate Vaccine Against SARS‐CoV‐2

Olivia Martínez, Darielys Santana-Mederos, Satomy Pousa, Jean Pierre Soubal et autres

ABSTRACT SOBERANA 02 is a safe and effective anti‐SARS‐CoV‐2 conjugate vaccine, produced using the maleimide‐thiol chemistry. In this vaccine, Cys 538 in the recombinant receptor binding domain (RBD) of SARS‐CoV‐2 is linked through a N ‐thiosuccinimidopropionyl linker to lysine residues of tetanus …

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Molecular Basis of Siglec-7 Recognition by Neisseria meningitidis Serogroup Y CPS: Implications for Immune Evasion

Cristina Di Carluccio, Tania Gerpe Amor, María Pia Lenza, A. Masi et autres

Siglecs, sialic-acid-binding immunoglobulin-like lectins, are key immune cell receptors that recognize sialic acid residues on cell surfaces. Pathogens and tumor cells exploit Siglecs to evade immune responses and modulate immunity, contributing significantly to infectious disease and cancer pathogenesis. Siglec-7, primarily expressed on …

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LC-MS/MS characterization of SOBERANA ® 02, a receptor binding domain-tetanus toxoid conjugate vaccine against SARS-CoV-2

Olivia Martínez, Darielys Santana-Mederos, Satomy Pousa, Jean Pierre Soubal et autres

Abstract SOBERANA ® 02 is a safe and effective conjugate vaccine against SARS-CoV-2, produced using the maleimide-thiol chemistry. In this vaccine, the Cys 538 in the recombinant receptor binding domain (RBD) of SARS-CoV-2 is linked, through a thiosuccinimide linker, to lysine residues …

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Safety and durability of the immune response after vaccination with the heterologous schedule of anti-COVID-19 vaccines SOBERANA®02 and SOBERANA® Plus in children 3–18 years old

Dagmar García-Rivera, Rinaldo Puga-Gómez, Sonsire Fernández-Castillo, Beatriz Paredes-Moreno et autres

Background: The heterologous three-dose schedule of the protein subunit anti-COVID-19 SOBERANA®02 and SOBERANA® Plus vaccines has proved its safety, immunogenicity and efficacy in pediatric population, but durability of immunogenicity is not yet dilucidated. This study reports the safety and durability of the …

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Comparative assessment of a COVID-19 vaccine after technology transfer to Iran from critical quality attributes to clinical and immunogenicity aspects

Delaram Doroud, Mona Sadat Larijani, Alireza Biglari, Fatemeh Ashrafian et autres

During COVID-19 pandemic, international pharmaceutical companies put effort to build global manufacturing networks for vaccines. Soberana Plus vaccine, a recombinant protein based vaccine (RBD dimer), with the trade name of PastoCovac Plus in Iran, is based on a protein subunit platform in …

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Effect of O‐Acetylation on the Antigenicity and Glycoconjugate Immunogenicity of the Streptococcus Pneumoniae Serotype 7F Capsular Polysaccharide

Jean Pierre Soubal, Aloyma Lugo, Darielys Santana-Mederos, Raine Garrido et autres

Streptococcus pneumoniae is a bacterial pathogen causing diseases as severe as pneumonia, sepsis and meningitis. Most commercial pneumococcal conjugate vaccines contain the 7F serotype, which is epidemiologically relevant and highly invasive. This serotype contains an O-acetyl group at the internal L-rhamnose of …

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Synthesis of oligosaccharides from terminal B. pertussis LPS pentasaccharide and definition of the minimal epitope recognized by anti-pertussis antibodies

Guang‐Wu Chen, Li‐Na Guo, Jiasheng Huang, Haijun Ma et autres

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Real-world effectiveness of the heterologous SOBERANA-02 and SOBERANA-Plus vaccine scheme in 2–11 years-old children during the SARS-CoV-2 Omicron wave in Cuba: a longitudinal case-population study

María Eugenia Toledo-Romaní, Carmen Valenzuela‐Silva, Minerva Montero-Díaz, Luisa Iñiguez-Rojas et autres

Background: Increased pediatric COVID-19 occurrence due to the SARS-CoV-2 Omicron variant has raised concerns about the effectiveness of existing vaccines. The protection provided by the SOBERANA-02-Plus vaccination scheme against this variant has not yet been studied. We aimed to evaluate the scheme's …

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Comparative Immune Response after Vaccination with SOBERANA® 02 and SOBERANA® plus Heterologous Scheme and Natural Infection in Young Children

Rocmira Pérez-Nicado, Chiara Massa, Laura Rodríguez-Noda, Anja Müller et autres

(1) Background: In children, SARS-CoV-2 infection is mostly accompanied by mild COVID-19 symptoms. However, multisystem inflammatory syndrome (MIS-C) and long-term sequelae are often severe complications. Therefore, the protection of the pediatric population against SARS-CoV-2 with effective vaccines is particularly important. Here, we …

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Real-World Effectiveness of the OBERANA02 and SOBERANA-Plus Vaccine Combination in Children 2 to 11 Years of Age during the SARS CoV-2 Omicron Wave in Cuba: A Regression Discontinuity Study

María Eugenia-Toledo-Romaní, Carmen Valenzuela‐Silva, Minerva Montero-Díaz, Luisa Iñiguez-Rojas et autres

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