Massimo Fresta

Where Tradition Meets Innovation: Integrating Historical Collections, Cadaveric Dissection, and Digital Technologies in Anatomy Education

Giuseppa D’Amico, M Di Marco, Giuseppe Vergilio, Francesca Monachino et autres

Backgrond/Objectives: Human anatomy education has traditionally relied on cadaveric dissection as the reference standard for acquiring anatomical knowledge. However, decreasing availability of donated bodies, curricular changes, and rapid technological advances have encouraged the progressive integration of complementary educational resources, including historical anatomical …

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Oxidative cues as theranostic switches for the ROS-responsive Nanotheranostics in oxidative stress-driven diseases

Shameer Pillarisetti, Rosanna Alfieri, Paola Palumbo, Bruno Filipe Carmelino Cardoso Sarmento et autres

Nanotheranostics (NTs) are nanoscale systems that combine disease diagnosis and targeted therapy. They often respond to specific signals, such as reactive oxygen species (ROS). These platforms leverage elevated ROS levels associated with diseases, such as neurodegeneration, cancer, cardiovascular disorders, and inflammation, to …

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Hybrid patch based on fast-dissolving electrospun nanocomposite membrane for local inflammation treatment

Pantaleone Bruni, Luigi Ciriolo, Nicola d'Avanzo, Maria Chiara Cristiano et autres

Rose petal-derived nanovesicles as a sustainable and functional ingredient for next-generation cosmetics

Antônio Alci Barone, Antonia Mancuso, Maria Chiara Cristiano, Jocelyn E. Sacco et autres

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Self-assembling rose-derived nanovesicles: A multifunctional tool for tissue regeneration

Antonella Barone, Luigi Ciriolo, Salvatore Panza, Nicola d’Avanzo et autres

The development of biocompatible nanotherapeutics for skin regeneration remains a major goal in regenerative medicine. Here, we report the isolation and characterization of rose petal-derived extracellular vesicle-like nanovesicles (RPDNVs) obtained by differential ultracentrifugation and size exclusion chromatography. Comprehensive physicochemical analyses confirmed their …

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Microfluidic Design of Ultradeformable Liposomes for Advanced Skin Delivery of Stellaria media Phytocomplex

Luigi Ciriolo, Nicola d’Avanzo, Antonia Mancuso, Maria Chiara Cristiano et autres

Background/Objectives: Ultradeformable liposomes represent an established platform for topical delivery of antioxidant compounds, thanks to their structural flexibility and ability to enhance skin permeation, but standardized manufacturing protocols are still lacking. This study presents a microfluidic-based strategy for the scalable production of …

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Exploring the potential of combining menthol-thymol deep eutectic solvent and solid microneedles for cutaneous peptide delivery

Shabir Ahmad, Grzegorz S Czyrski, Christian Janfelt, Stéphanie Baud et autres

While cutaneous administration of bioactive molecules like peptides offers advantages over oral delivery by bypassing first-pass metabolism and increasing bioavailability, it also comes with some challenges, primarily due to poor peptide absorption through the lipophilic stratum corneum, as a result of peptide …

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LinTT1-Functionalized Hybrid Lipid–Polymer Nanoparticles for Glioblastoma Targeting

Antonella Rocchi, Valeria Sidorenko, Nicola d’Avanzo, Luca Marchetti et autres

High Resolution Image Download MS PowerPoint Slide Glioblastoma multiforme (GBM) is an aggressive brain tumor with limited therapeutic options and a poor prognosis. We developed hybrid lipid-polymer nanoparticles (HLPNs) functionalized with tumor-homing C-end Rule peptide LinTT1 (LinTT1-HLPNs) to improve the GBM targeting. …

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Assessing effectiveness of multistage nanomedicines for multidrug therapy of vitiligo

Antonia Mancuso, Maria Chiara Cristiano, Nicola d’Avanzo, Salvatore Panza et autres

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Multi-stage therapeutic device based on fast dissolving electrospun nano-composite fiber membranes for local inflammation treatment

Pantaleone Bruni, Luigi Ciriolo, Nicola d apos Avanzo, Maria Chiara Cristiano et autres

Self-assembling rose-derived nanovesicles: a multifunctional tool for tissue regeneration

Antonella Barone, Luigi Ciriolo, Salvatore Panza, Nicola d apos Avanzo et autres

it (code pays fourni par la source)

Rutin-loaded zein gel as a green biocompatible formulation for wound healing application

Agnese Gagliardi, Elena Giuliano, Silvia Voci, Nicola Costa et autres

Wound healing is a challenging clinical problem and efficient wound management is essential to prevent infection. This is best done by utilizing biocompatible materials in order to complete the healing in a rapid manner, with functional and esthetic outcomes. In this context, …

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