Mike Gattas

Clarifying risk-factor associations with quantitative breast tumor features: a pooled analysis of 24 studies

Daniel Adams, Amber N. Hurson, Thomas U Ahearn, Irene L Andrulis et autres

BACKGROUND: Breast cancer is etiologically heterogeneous, but which risk factors differ in their associations across tumor subtypes remains unclear. We conducted a large, pooled analysis to evaluate independent, dose-response associations between breast cancer risk factors and quantitative tumor features. METHODS: Analyses of …

us, ca, gb, fi, de, pl, nl, au, es, sg (code pays fourni par la source)

Parity and lactation induce T-cell-mediated breast cancer protection

Balaji Virassamy, Franco Caramia, Peter Savas, Michael A. Harris et autres

Parity and breastfeeding reduce the risk of breast cancer, particularly triple-negative breast cancer (TNBC) 1,2 , yet the immunological mechanisms underlying this protection remain unclear. Here, we show that parity induces an accumulation of CD8 + T cells, including cells with a …

au, my, be, nz, gb (code pays fourni par la source)

Hormonal Contraception and Breast Cancer Risk for Carriers of Germline Mutations in BRCA1 and BRCA2

Kelly‐Anne Phillips, Joanne Kotsopoulos, Susan M. Domchek, Mary Beth Terry et autres

PURPOSE It is uncertain whether, and to what extent, hormonal contraceptives increase breast cancer (BC) risk for germline BRCA1 or BRCA2 mutation carriers. METHODS Using pooled observational data from four prospective cohort studies, associations between hormonal contraceptive use and BC risk for …

au, ca, us, pl, at (code pays fourni par la source)

Pregnancy-Related Factors and Breast Cancer Risk for Women Across a Range of Familial Risk

Jasmine A. McDonald, Yuyan Liao, Julia A. Knight, Esther M. John et autres

Importance: Few studies have investigated whether the associations between pregnancy-related factors and breast cancer (BC) risk differ by underlying BC susceptibility. Evidence regarding variation in BC risk is critical to understanding BC causes and for developing effective risk-based screening guidelines. Objective: To …

us, ca, cn, au (code pays fourni par la source)

Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset

Aimee L. Davidson, Kyriaki Michailidou, Michael T. Parsons, Cristina Fortuño et autres

au, gb, cy, us, es, ca, fi, de, ru, by, dk, nl, se, pl, fr, sg (code pays fourni par la source)

Cancer Risks Associated With TP53 Pathogenic Variants: Maximum Likelihood Analysis of Extended Pedigrees for Diagnosis of First Cancers Beyond the Li-Fraumeni Syndrome Spectrum

Cristina Fortuño, Bing Feng, Courtney Carroll, Giovanni Innella et autres

PURPOSE Establishing accurate age-related penetrance figures for the broad range of cancer types that occur in individuals harboring a pathogenic germline variant in the TP53 gene is essential to determine the most effective clinical management strategies. These figures also permit optimal use …

au, us, it, es (code pays fourni par la source)

The impact of coding germline variants on contralateral breast cancer risk and survival

Anna Morra, Nasim Mavaddat, Taru Muranen, Thomas U. Ahearn et autres

Evidence linking coding germline variants in breast cancer (BC)-susceptibility genes other than BRCA1, BRCA2, and CHEK2 with contralateral breast cancer (CBC) risk and breast cancer-specific survival (BCSS) is scarce. The aim of this study was to assess the association of protein-truncating variants …

nl, gb, fi, us, ca, de, dk, es, au, se, fr, pl, no, it, gr (code pays fourni par la source)

FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women

Gisella Figlioli, Amandine Billaud, Thomas U. Ahearn, Natalia Antonenkova et autres

Evidence from literature, including the BRIDGES study, indicates that germline protein truncating variants (PTVs) in FANCM confer moderately increased risk of ER-negative and triple-negative breast cancer (TNBC), especially for women with a family history of the disease. Association between FANCM missense variants …

it, us, by, de, es, ru, nl, gb, no, se, fr, cy, au, nz (code pays fourni par la source)

Mendelian randomisation study of smoking exposure in relation to breast cancer risk

Hanla A. Park, Sonja Neumeyer, Kyriaki Michailidou, Manjeet K. Bolla et autres

BACKGROUND: Despite a modest association between tobacco smoking and breast cancer risk reported by recent epidemiological studies, it is still equivocal whether smoking is causally related to breast cancer risk. METHODS: We applied Mendelian randomisation (MR) to evaluate a potential causal effect …

de, gb, cy, us, ca, by, se, be, es, ru, dk, it, au, no, nl, fi, fr (code pays fourni par la source)

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk

Iris Kramer, Maartje J. Hooning, Nasim Mavaddat, Michael Hauptmann et autres

nl, gb, de, il, ca, us, se, es, ru, by, dk, it, hk, au, kr, sg, tw, jp, mk, pl, no, be, fi, gr (code pays fourni par la source)

Development and validation of a targeted gene sequencing panel for application to disparate cancers

Mark J. McCabe, Chia-Ling Chan, Tanya Thompson, Sunita M C De Sousa et autres

Next generation sequencing has revolutionised genomic studies of cancer, having facilitated the development of precision oncology treatments based on a tumour's molecular profile. We aimed to develop a targeted gene sequencing panel for application to disparate cancer types with particular focus on …

au, ch, nz, gb (code pays fourni par la source)

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer

Gisella Figlioli, Massimo Bogliolo, Irene Catucci, Laura Caleca et autres

Abstract Breast cancer is a common disease partially caused by genetic risk factors. Germline pathogenic variants in DNA repair genes BRCA1, BRCA2, PALB2, ATM, and CHEK2 are associated with breast cancer risk. FANCM, which encodes for a DNA translocase, has been proposed …

it, es, us, fi, gb, cy, nl, au, is, by, de, ca, at, il, ru, se, dk, be, fr, pl, ch, Afrique du Sud (code pays fourni par la source)