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Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Figure S5: Combined toxicity of LB-100 and Adavosertib in PDAC and CCA models (A) and (B) Dose-response assays show the effect of LB-100 or Adavosertib in 4 PDAC and 4 CCA models, respectively. Cell viability was estimated by resazurin fluorescence after 5 …
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Figure S7: Normal tissues from the orthotopic CRC PDXs are not affected by LB-100, adavosertib, or the combination. Representative Hematoxylin & Eosin (H&E) stainings of the heart, liver, lung, and spleen from the PDOX1 PDXs treated as indicated. Original magnifications are indicated.
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Figure S8: Acquired resistance to the combination of LB-100 and adavosertib suppressed malignant traits in CRC models (A) IncuCyte-based proliferation assays from HT-29 and SW-480 parental and resistant cells in the absence or presence of the combination (LB-100 4 µM + adavosertib …
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Figure S6: LB-100 and adavosertib induce histological response in orthotopic CRC PDXs (A) Representative Hematoxylin & Eosin (H&E) stainings at endpoint from PDOX2 and PDOX3 treated as indicated. Original magnification middle images: 15x, scale bar 1000 µm; right images: 200x. S indicates …
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Supplementary table 1: Cancer cell lines with oncogenic drivers The mutational status of the cell lines was compiled from the ATCC, Catalogue of Somatic Mutations in Cancer (COSMIC) and Cell Model Passport, Wellcome Trust Sanger Institute, and Depmap portal databases.
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Figure S3: High N-Myc levels sensitize neuroblastoma cells to LB-100, and PP2A knockdown sensitizes CRC cells to WEE1 inhibition (A) Western blots comparing N-Myc levels in isogenic neuroblastoma models. GAPDH was used as a loading control. (B) long-term viability assays compares the …
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Supplementary table 4: The composition of the stress-focused drug library Compounds comprising the stress-focused drug library with their respective targets.
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Supplementary table 5: Stress-focused drug screens AUC differences in HT-29 cells Area Under the Curve (AUC) from each compound of the stress-focused drug screen in the presence or absence of LB-100. Compounds are ranked by the difference in the AUC between LB-100-treated …
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Figure S1: LB-100 engages stress-related, inflammatory response, and mitogenic signaling transcriptional programs in CRC cells (A) Dose-response assays show the effect of LB-100 in 7 CRC models. Cell viability was estimated by resazurin fluorescence after 5 days in the presence of the …
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Figure S10: Acquired resistance to the combination of LB-100 and Adavosertib suppress anchorage-independent and tumor growth in CRC models (A) Endpoint proliferation of HT-29 and SW-480 parental and resistant cells growing attached or in anchorage-independent conditions. Cells were plated in the same …
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Supplementary table 7: Full list of genes whose knockout was selectively toxic in the presence of LB-100 in SW-480 cells in the CRISPR-KO screen FDR smaller or equal to 0.25 and log2 fold change smaller or equal to -1 in treated/untreated comparison …
Matheus Henrique Dias, Anoek Friskes, Siying Wang, João M. Fernandes Neto et autres
Figure S1: LB-100 engages stress-related, inflammatory response, and mitogenic signaling transcriptional programs in CRC cells (A) Dose-response assays show the effect of LB-100 in 7 CRC models. Cell viability was estimated by resazurin fluorescence after 5 days in the presence of the …
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