F. Cachin

Development and validation of a PSMA-positive triple-negative breast cancer mouse model for preclinical targeted radionuclide therapies

Benjamin Chaussin, Lucie Sanchez, Sophie Lévesque, Alban Revy et autres

Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, for which targeted therapies are emerging. Prostate-specific membrane antigen (PSMA), expressed mainly by the endothelial cells of the neovascularization of TNBC, or tumor cells, is an interesting target in TNBC …

fr, mc (code pays fourni par la source)

Effects of Low‐to‐Moderate Ionizing Radiation on Human Sperm Function and DNA Integrity

Oriana Carcy, N. Sas, M. Chanchou, Tommy Billoux et autres

BACKGROUND: Ionizing radiation is widely used in medical diagnostics and cancer therapy, notably radioiodine therapy for thyroid carcinoma. While high or repeated ionizing radiation doses are known to impair male fertility, the impact of clinically relevant single-dose exposures on sperm functional and …

fr (code pays fourni par la source)

Use of shared warm waiting rooms in nuclear medicine: quantitative analysis of staff and patient exposures

G. Bonardel, Eric J. Gonzalez, Ayinkamiye Milly-Rivière, Agathe Edet‐Sanson et autres

The organization of nuclear medicine facilities, particularly those dedicated to PET, must balance quality of care and radiation protection in accordance with the ALARA principle. The evolution of PET technologies and the integration of AI improve sensitivity and allow large reductions in …

gb, fr, us (code pays fourni par la source)

18F-Fluorodeoxyglucose PET-CT evaluation after one course of neoadjuvant therapy fails to predict pCR in HER2 + BC patients: a prospective and multicentric French study

M. Chanchou, Marie‐Ange Mouret‐Reynier, Ioana Molnar, Emmanuel Deshayes et autres

18 F–FDG PET–CT has emerged as a powerful imaging tool for initial staging and prognosis evaluation of patients with Breast Cancer (BC). However, previous studies are inconsistent on attributing a predictive value to the pathological Complete Response (pCR) determined by PET–CT. Our …

fr, us, lu (code pays fourni par la source)

Radiothérapie interne vectorisée du mélanome métastatique : détermination de l’activité injectée optimale, dosimétrie personnalisée et tolérance de l’131I-ICF01012 (essai clinique de phase I)

Jacques Rouanet, M. Chanchou, Philippe Auzeloux, Sarah Lévesque et autres

fr (code pays fourni par la source)

Tumor sink effect on melanin-ligand [131I]ICF01012 in melanoma and its implications for targeted radionuclide therapy

E. Jouberton, Sophie Besse, Tommy Billoux, Philippe Auzeloux et autres

The tumor sink effect refers to the sequestration of a radiopharmaceutical compound by tumors, leading to a reduced bioavailability in non-target organs and potential alterations in radiopharmaceuticals distribution. This phenomenon has been widely studied in neuroendocrine, thyroid, and prostate cancers but remains …

fr (code pays fourni par la source)

[99mTc]Tc-NTP 15 − 5, a new proteoglycan tracer for functional imaging of joint cartilage: phase I (CARSPECT)

M. Chanchou, Émilie Thivat, Sylvain Mathieu, Sophie Lévesque et autres

[99mTc]Tc-NTP 15 − 5 showed affinity for joint cartilage proteoglycans on preclinical studies but has not been tested in humans. This phase I trial (CARPECT: NCT04481230) aims to define the optimal of [99mTc]Tc-NTP 15 − 5 injected activity to obtain the best …

fr (code pays fourni par la source)

New three‐dimensional nuclear morphometry tool quantifies impact of slow freezing on sperm hypercondensed chromatin

Oriana Carcy, Sophie Desset, Tristan Dubos, Chloé Puceat et autres

BACKGROUND: Perm freezing compromises nuclear integrity. Standardized tools to assess three-dimensional (3D) chromatin alterations are lacking. OBJECTIVES: This study aimed to present a novel protocol for 3D nuclear morphometric analysis of human spermatozoa to measure slow freezing and thawing-induced alterations. MATERIALS AND …

fr (code pays fourni par la source)

P-041 Impact of ionizing radiation on human spermatozoa integrity

Hanae Pons‐Rejraji, Oriana Carcy, N.C.F. van Sas, N Billoux et autres

Abstract Study question Do ionizing radiations affect human sperm integrity? If so, at what dose? Summary answer In vitro exposure of human ejaculated spermatozoa significantly reduces vitality, motility, and chromatin integrity without causing DNA fragmentation, telomeric damage, or altering capacitation ability. What …

fr (code pays fourni par la source)

Développement d’un modèle d’étude in vitro 3D de cancer du sein triple négatif pour l’évaluation d’effets radiobiologiques

B. Chaussin, Do‐Hoon Kwon, A. Revy, Emmanuel Chautard et autres

fr (code pays fourni par la source)

Effet abscopal après radiothérapie interne vectorisée dans le mélanome métastatique : études précliniques dans un nouveau modèle murin double tumeur

Gilles Delmas, Benjamin Chaussin, Christopher Montemagno, E. Jouberton et autres

fr, mc (code pays fourni par la source)

Effet de la charge tumorale dans le traitement des mélanomes métastatiques par RIV ciblant la mélanine ([131I]ICF01012) : preuve de concept préclinique

E. Jouberton, S. Besse, Steffen Schmitt, Philippe Auzeloux et autres

fr (code pays fourni par la source)