Gauree Gupta Konijeti

Effectiveness and Safety of Extended Upadacitinib Induction Therapy in Adult Patients with Moderate-to-Severe Active Ulcerative Colitis

Nabil El Hage Chehade, Tara Alleyasin, Bonnie Zagorski, Thien Nguyen et autres

Abstract Background Responses to induction therapies for moderate-to-severe active ulcerative colitis (UC) are sufficient, but some patients benefit from prolonged induction to achieve clinical outcomes before transitioning to maintenance dosing. Upadacitinib (UPA), an oral JAK1 inhibitor, is approved in the US. for …

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Lumen-Apposing Metal Stent as a Bridge to Endoscopic Balloon Dilation for a Refractory Ileocolonic Anastomotic Crohn's Stricture

Hillary C. Smalley, Rohit Khanna, Matthew Skinner, Keith Beiermeister et autres

Strictures in Crohn's disease frequently involve ileocolonic anastomoses and may cause recurrent small bowel obstruction (SBO). Endoscopic balloon dilation (EBD) is effective but can be limited in complex strictures, and many patients ultimately require surgery. We report a 76-year-old man with long-standing …

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Metabolomic Profiling of Fecal Samples Reveals Distinct Signatures Associated with Disease Phenotypes and Locations in Crohn’s Disease

Tingyi Tan, Matthew Vincent, Umang K. Jain, Parakkal Deepak et autres

BACKGROUND: Crohn's disease is a heterogeneous, transmural inflammatory condition that can involve any segment of the gastrointestinal tract. Distinct locations (ileal, colonic, ileocolonic) and phenotypes (inflammatory, stricturing, penetrating) display different clinical behaviors and complication risks in CD. Whether these location- and phenotype-specific …

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S4030 A Diagnostic Puzzle: GI Amyloidosis Presenting With Non-Specific Colitis-Like Symptoms

Garrett Teskey, O. Daniëls, Collin Mayemura, Emma Z. Du et autres

Introduction: Amyloidosis is a condition caused by extracellular deposition of misfolded proteins forming β-pleated sheet fibrils that disrupt tissue structure and function. AL amyloidosis, the most common subtype, can involve the gastrointestinal (GI) tract in a subset of patients. GI involvement manifests …

S1570 Prior Biologic or Janus Kinase Inhibitor Therapy Does Not Impact Colectomy Rates Among Patients Needing Infliximab Rescue Therapy for Acute Severe Ulcerative Colitis

Sang Hee Choi, Rohit Khanna, Olivia Lanser, Thien Nguyen et autres

Introduction: Infliximab (IFX) is recommended for steroid-refractory patients hospitalized with acute severe ulcerative colitis (ASUC). However, limited data exist on its efficacy in patients with prior exposure to advanced therapies (AT), including biologics or janus kinase (JAK) inhibitors. This study examines the …

S4868 Recurrent Abdominal Abscesses and Fistulas: A Tricky Diagnosis of Intestinal Tuberculosis Mimicking Crohn’s Disease in a High-Risk Patient

Rohit K. Khanna, Joy-Marie J. Hermes, Olivia Lanser, Ali Y. Fakhreddine et autres

Introduction: Intestinal tuberculosis (TB) is rare in the U.S. and is a diagnostic challenge, mimicking infection and inflammatory bowel disease. Symptoms are nonspecific and complications include intestinal ulcers, strictures, fistulas, ascites or perforation. We present a case of serologic negative intestinal TB …

S4937 Novel Use of Lumen Apposing Metal Stents for Complicated Anastomotic Crohn's Strictures

Hillary C. Smalley, Rohit K. Khanna, Matthew J. Skinner, Keith Beiermeister et autres

Introduction: Strictures in Crohn's disease (CD), affecting native bowel and surgical anastomoses, particularly ileocolonic anastomoses (ICA). Endoscopic balloon dilation is often effective, though limitations include stricture length, angulation, and ulceration. Partially covered metal stents might effectively treat short CD strictures, but they …

S1976 Does One Precede the Other? Clinical Course of Patients With Concomitant Eosinophilic Esophagitis and Inflammatory Bowel Disease

Garrett Teskey, Collin Mayemura, Evan Wilder, Leah H. Puglisi et autres

Introduction: Eosinophilic esophagitis (EoE) and inflammatory bowel disease (IBD) are chronic immune-mediated conditions that may co-occur, suggesting a possible shared underlying pathophysiologic mechanism. A few studies have explored the potential temporal relationship between these conditions, however, the factors influencing their sequence remain …

Sa1020: ASSESSING RACE- AND AGE-BASED DISPARITIES AMONG ADVANCED THERAPY USE AMONG PATIENTS WITH INFLAMMATORY BOWEL DISEASE

Olivia Lanser, Oluwaposi Omiwade, Leah H. Puglisi, Melissa J. Ferrari et autres

395: REVOLUTIONIZING IBD TRAINING: IMPLEMENTATION OF POINT-OFCARE INTESTINAL ULTRASOUND CURRICULUM FOR GASTROENTEROLOGY FELLOWS AT A MULTICENTER INSTITUTION

Nabil El Hage Chehade, Joy-Marie J. Hermes, Ally Mazer, Rebecca Matro et autres

S4918 Infiltrative Monomorphic Epitheliotropic Intestinal T-Cell Lymphoma: A Case Report

Nabil El Hage Chehade, Vandan Patel, Olivia Lanser, Pranav Gandhi et autres

Introduction: Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare aggressive T-cell lymphoma more common in Asian and Hispanic populations. Review of the literature suggests most cases of MEITL manifest as small bowel tumors and present with bowel obstruction or perforation. Here, …

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S3894 Use of Risankizumab in a Patient with Recurrent Isolated Perianal Crohn's Disease Despite Total Proctocolectomy: A Case Report

Melissa Ferrari, Nabil El Hage Chehade, Olivia Lanser, Robert Brookover et autres

Introduction: Isolated perianal Crohn’s disease (CD) remains a challenging disease phenotype to manage despite therapeutic advances in Inflammatory bowel disease (IBD). Data supporting options beyond anti-Tumor necrosis factor (TNF) therapy in patients with perianal disease without luminal involvement is lacking. We report …

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