Profil bibliographique

Teresa G. Krieger

Informations fournies par OpenAlex. Research Africa ne déduit ni nationalité, ni poste, ni coordonnées personnelles.

40Publications signalées

1609Citations signalées

0Affiliations récentes

Les domaines associés

Cancer Genomics and DiagnosticsLung Cancer Treatments and MutationsSingle-cell and spatial transcriptomicsPancreatic and Hepatic Oncology ResearchCancer Cells and Metastasis

Les publications récentes

Accès ouvert 2026 preprint OpenAlex

Concept-based explanation of gene expression prediction from H&E images

Amos Muench, Jonathan Thielmann, Reduan Achtibat, Maximilian Dreyer et autres

Recent advances in pathology foundation models have enabled accurate prediction of spatial transcriptomics (ST) from routine H&E images. However, existing explainability methods for vision transformer (ViT)-based models are largely limited to local heatmaps and do not reveal how morphological concepts contribute to …

0 citations arXiv (Cornell University)

Accès ouvert 2026 preprint OpenAlex

Concept-based explanation of gene expression prediction from H&E images

Amos Muench, Jonathan Thielmann, Reduan Achtibat, Maximilian Dreyer et autres

Recent advances in pathology foundation models have enabled accurate prediction of spatial transcriptomics (ST) from routine H&E images. However, existing explainability methods for vision transformer (ViT)-based models are largely limited to local heatmaps and do not reveal how morphological concepts contribute to …

0 citations arXiv (Cornell University)

Accès ouvert 2025 other OpenAlex

Figure S2 from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Supplementary Figure S2 shows simulation results of clonogenic assays under copy number-dependent and -independent cell fitness

0 citations

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Figure S5 from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Supplementary Figure S5 shows copy number dynamics in ecDNA vs. HSR neuroblastoma cells in response to cytotoxic and targeted therapies

0 citations

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Figure S4 from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Supplementary Figure S4 provides computational and experimental models of ecDNA-dependent treatment responses in neuroblastoma

0 citations

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Table S4 from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Supplementary Table S4 contains information about the MYCN status of neuroblastoma patient samples used in Figure 1 and Supplementary Figure 1

0 citations

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Table S2 from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Supplementary Table S2 lists the GDCS compounds used in Supplementary Figure S4L

0 citations

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Table S3 from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Supplementary Table S3 contains information about the MYCN and TP53 status of cell lines used in Supplementary Figure S4L

0 citations

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Data from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Abstract Extrachromosomal DNA (ecDNA) amplification enhances intercellular oncogene dosage variability and accelerates tumor evolution by violating foundational principles of genetic inheritance through its asymmetric mitotic segregation. Spotlighting high-risk neuroblastoma, we demonstrate how ecDNA amplification undermines the clinical efficacy of current therapies in …

0 citations

Accès ouvert 2025 other OpenAlex

Figure S1 from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Supplementary Figure S1 characterises the MYCN amplification status, copy number heterogeneity and growth behaviour in neuroblastoma samples

0 citations

Accès ouvert 2025 other OpenAlex

Figure S7 from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Supplementary Figure S7 demonstrates the impact of MYCN dosage on treatment response in neuroblastoma

0 citations

Accès ouvert 2025 other OpenAlex

Table S1 from Extrachromosomal DNA–Driven Oncogene Dosage Heterogeneity Promotes Rapid Adaptation to Therapy in MYCN-Amplified Cancers

Giulia Montuori, Fengyu Tu, Di Qin, Rachel Schmargon et autres

Supplementary Table S1 contains FISH proteomics datasets

0 citations

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