Ali Raza Gardezi

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

John F. Peden, Martin Farrall, Anuj Goel, Halit Ongen et autres

gb, se, pk, fr, fi, de, us, jp, pl, it, ch, nl, gr, ca (code pays fourni par la source)

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

John F. Peden, Jemma C. Hopewell, Danish Saleheen, John C. Chambers et autres

Genome-wide association studies have identified 11 common variants convincingly associated with coronary artery disease (CAD)¹⁻⁷, a modest number considering the apparent heritability of CAD⁸. All of these variants have been discovered in European populations. We report a meta-analysis of four large genome-wide …

gb, se, de, us, fi, nl, gr, ca (code pays fourni par la source)

Genetic Determinants of Major Blood Lipids in Pakistanis Compared With Europeans

Danish Saleheen, Nicole Soranzo, Asif Rasheed, Hubert Scharnagl et autres

BACKGROUND: Evidence is sparse about the genetic determinants of major lipids in Pakistanis. METHODS AND RESULTS: Variants (n=45 000) across 2000 genes were assessed in 3200 Pakistanis and compared with 2450 Germans using the same gene array and similar lipid assays. We …

gb (code pays fourni par la source)

Association of the 9p21.3 Locus With Risk of First-Ever Myocardial Infarction in Pakistanis

Danish Saleheen, M Alexander, Asif Rasheed, David Wormser et autres

OBJECTIVE: To examine variants at the 9p21 locus in a case-control study of acute myocardial infarction (MI) in Pakistanis and to perform an updated meta-analysis of published studies in people of European ancestry. METHODS AND RESULTS: A total of 1851 patients with …

us, gb (code pays fourni par la source)

The Pakistan Risk of Myocardial Infarction Study: a resource for the study of genetic, lifestyle and other determinants of myocardial infarction in South Asia

Danish Saleheen, Moazzam Zaidi, Asif Rasheed, Usman Ahmad et autres

The burden of coronary heart disease (CHD) is increasing at a greater rate in South Asia than in any other region globally, but there is little direct evidence about its determinants. The Pakistan Risk of Myocardial Infarction Study (PROMIS) is an epidemiological …

pk, gb (code pays fourni par la source)