Nathan J. Brown

Structural basis of MPL activation by thrombopoietin

Amirhossein Mafi, Matthew A. Bratkowski, Jiefei Geng, Alyssa Brito et autres

Myeloproliferative leukemia protein (MPL), also known as thrombopoietin (TPO) receptor, is a class I cytokine receptor that is expressed on hematopoietic progenitors, promoting growth and differentiation toward the megakaryocyte lineage and is critical for normal platelet production. Mutations in MPL, TPO, or …

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Broad proteomics analysis of seeding-induced aggregation of α-synuclein in M83 neurons reveals remodeling of proteostasis mechanisms that might contribute to Parkinson’s disease pathogenesis

Casey J. Lumpkin, Hiral S. Patel, Gregory K. Potts, Shilpi Chaurasia et autres

Aggregation of misfolded α-synuclein (α-syn) is a key characteristic feature of Parkinson's disease (PD) and related synucleinopathies. The nature of these aggregates and their contribution to cellular dysfunction is still not clearly elucidated. We employed mass spectrometry-based total and phospho-proteomics to characterize …

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An anti–TNF–glucocorticoid receptor modulator antibody-drug conjugate is efficacious against immune-mediated inflammatory diseases

Michael J. McPherson, Adrian D. Hobson, Axel Hernández, Christopher C. Marvin et autres

Glucocorticoids (GCs) are efficacious drugs used for treating many inflammatory diseases, but the dose and duration of administration are limited because of severe side effects. We therefore sought to identify an approach to selectively target GCs to inflamed tissue. Previous work identified …

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Validation and long term performance characteristics of a quantitative enzyme linked immunosorbent assay (ELISA) for human anti-PA IgG

Vera A. Semenova, Jarad M. Schiffer, Evelene Steward‐Clark, Stephen D. Soroka et autres

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