Adriano Angelucci

rhNGF shows neuroprotective efficacy by counteracting oxidative stress and neuroinflammation in a glaucoma mouse model

Davide Vecchiotti, Mauro Di Vito Nolfi, Chiara Compagnoni, Martina Sara Miscione et autres

Abstract Glaucoma is a neurodegenerative condition characterised by the progressive loss of retinal ganglion cells (RGCs) and irreversible vision impairment and one of the leading causes of blindness worldwide. Current treatments primarily focus on reducing intraocular pressure (IOP), yet many patients continue …

it, gb (code pays fourni par la source)

Exploration of miR-326 delivery via biocompatible polymeric nanoparticles in medulloblastoma: A preliminary study

Elena Splendiani, Gabriele Maiorano, Zaira Spinello, Davide Vecchiotti et autres

MicroRNAs play a crucial role in tumorigenesis, functioning as oncogenes or tumor-suppressors while orchestrating the differentiation states of cancer cells. In medulloblastoma, the most common malignant pediatric brain tumor, the downregulation of miR-326 is associated with a loss of tumor suppression that …

it (code pays fourni par la source)

NF-κB Involvement in Glaucoma-Associated Neuroinflammation: Focus on Glial Cells

Francesca Veglianti, Mauro Di Vito Nolfi, Irene Flati, Francesca Dall’Aglio et autres

Glaucoma is a complex neurodegenerative disease characterized by the progressive loss of retinal ganglion cells (RGCs) and optic nerve damage. Both mechanical and vascular factors are believed to contribute to the etiology of glaucoma. However, the underlying pathogenic mechanisms are not yet …

it (code pays fourni par la source)

Evaluation of Antitumoral Activity in a 3D Cell Model of a Src Inhibitor Prodrug for Glioblastoma Treatment

Letizia Clementi, Federica Poggialini, Francesca Musumeci, Julia Taglienti et autres

Background: Three-dimensional (3D) cell models may bridge the gap between two-dimensional (2D) cell cultures and animal models. Technical advances have led to the development of 3D-bioprinted cell models, characterized by greater reproducibility and the ability to mimic in vivo conditions. Glioblastoma multiforme …

it (code pays fourni par la source)

A 3D Bioprinting Approach to Studying Retinal Müller Cells

Davide Vecchiotti, Mauro Di Vito Nolfi, Francesca Veglianti, Francesca Dall’Aglio et autres

Background/Objectives: Bioprinting is an innovative technology in tissue engineering, enabling the creation of complex biological structures. This study aims to develop a three-dimensional (3D) bioprinted model of Müller cells (MCs) to enhance our understanding of their physiological and pathological roles in the …

it (code pays fourni par la source)

Evidence of the Link between Stroma Remodeling and Prostate Cancer Prognosis

Davide Vecchiotti, Letizia Clementi, Emanuele Cornacchia, Mauro Di Vito Nolfi et autres

Prostate cancer (PCa), the most commonly diagnosed cancer in men worldwide, is particularly challenging for oncologists when a precise prognosis needs to be established. Indeed, the entire clinical management in PCa has important drawbacks, generating an intense debate concerning the possibility to …

it (code pays fourni par la source)

In-vitro Approaches to Investigate the Detrimental Effect of Light on Dopaminergic Neurons

Irene Fasciani, Francesco Petragnano, Federica Bono, Gabriella Aloisi et autres

Our recent study revealed that fluorescent lamp light can penetrate deep into the brain of mice and rats leading to the development of typical histological characteristics associated with Parkinson's disease such as the loss of dopamine neurons in the substantia nigra. Monochromatic …

it (code pays fourni par la source)

MiR-182-5p Is Upregulated in Hepatic Tissues from a Diet-Induced NAFLD/NASH/HCC C57BL/6J Mouse Model and Modulates Cyld and Foxo1 Expression

Chiara Compagnoni, Roberta Capelli, Veronica Zelli, Alessandra Corrente et autres

Non-alcoholic fatty liver disease (NAFLD) is considered a relevant liver chronic disease. Variable percentages of NAFLD cases progress from steatosis to steatohepatitis (NASH), cirrhosis and, eventually, hepatocellular carcinoma (HCC). In this study, we aimed to deepen our understanding of expression levels and …

it (code pays fourni par la source)

Long-term beneficial impact of the randomised trial ‘Train the Brain’, a motor/cognitive intervention in mild cognitive impairment people: effects at the 14-month follow-up

Alessandro Sale, Marianna Noale, Simona Cintoli, Gloria Tognoni et autres

No treatment options are currently available to counteract cognitive deficits and/or delay progression towards dementia in older people with mild cognitive impairment (MCI). The 'Train the Brain' programme is a combined motor and cognitive intervention previously shown to markedly improve cognitive functions …

it, cz, ch (code pays fourni par la source)

Supplementary data from Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

Alessia Calgani, Claudio Zamperini, Federica Coniglio, Claudio Festuccia et autres

Supplementary table s1 + supplementary methods

Supplementary data from Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

Alessia Calgani, Claudio Zamperini, Federica Coniglio, Claudio Festuccia et autres

Supplementary table s1 + supplementary methods

Data from Suppression of SRC Signaling Is Effective in Reducing Synergy between Glioblastoma and Stromal Cells

Alessia Calgani, Claudio Zamperini, Federica Coniglio, Claudio Festuccia et autres

Abstract Glioblastoma cells efficiently interact with and infiltrate the surrounding normal tissue, rendering surgical resection and adjuvant chemo/radiotherapy ineffective. New therapeutic targets, able to interfere with glioblastoma's capacity to synergize with normal brain tissue, are currently under investigation. The compound Si306, a …