Richard Fahrner

Activating a B cell immune response regresses immunologically cold tumours

Heena Aggarwal, Nimish Gupta, Aniruddha Sengupta, Arindam Sarkar et autres

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919 Preclinical characterization of a first-in-class RNA/DNA hybrid TLR7/8/9 agonist, Z-007, ex vivo in human tumor-associated cells, in vivo in mice and primates, and tumor regression in mice

Arthur Μ. Krieg, Evan Walters, James Barsoum, Thomas Broome et autres

Background Viral nucleic acids are detected by TLR7/8 (RNA) and TLR9 (DNA). Recently, vidutolimod, the first CpG-A TLR9 agonist, showed systemic monotherapy activity (9/40 responses) in PD-1 blockade-resistant melanoma. 1 In the randomized ECOG-ACRIN EA6194 trial in neoadjuvant melanoma, the addition of …

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Synthesis and Characterization of Fatty Acid Conjugates of Niacin and Salicylic Acid

Chi B. Vu, Jean E. Bemis, Ericka L. Benson, Pradeep Bista et autres

This report describes the synthesis and preliminary biological characterization of novel fatty acid niacin conjugates and fatty acid salicylate conjugates. These molecular entities were created by covalently linking two bioactive molecules, either niacin or salicylic acid, to an omega-3 fatty acid. This …

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