Accès ouvert
2025
article
OpenAlex
Abhi Aggarwal, Adrian Negrean, Yang Chen, Rishyashring R. Iyer et autres
Understanding how neurons integrate signals from thousands of input synapses requires methods to monitor neurotransmission across many sites simultaneously. The fluorescent protein glutamate indicator iGluSnFR enables visualization of synaptic signaling, but the sensitivity, scale and speed of such measurements are limited by …
us, ca, de, gb, at, it
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Kaspar Podgorski, Abhi Aggarwal, Adrian Negrean, Yang Chen et autres
us, gb, de, at, it
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Ilya Kolb, J. Hasseman, Akihiro Matsumoto, Benjamin Arthur et autres
Abstract Monitoring GABAergic inhibition in the nervous system has been enabled by development of an intensiometric molecular sensor that directly detects GABA. However, the first generation iGABASnFR exhibits low signal-to-noise and suboptimal kinetics, making in vivo experiments challenging. To improve sensor performance, …
us, jp, gb
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Abhi Aggarwal, Adrian Negrean, Yang Chen, Rishyashring R. Iyer et autres
Abstract Identifying the input-output operations of neurons requires measurements of synaptic transmission simultaneously at many of a neuron’s thousands of inputs in the intact brain. To facilitate this goal, we engineered and screened 3365 variants of the fluorescent protein glutamate indicator iGluSnFR3 …
us, ca, de, fr, gb, at, it
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Pablo Samuel Castro, Nenad Tomašev, Ankit Anand, Rishika Mohanta et autres
Symbolic models play a key role in cognitive science, expressing computationally precise hypotheses about how the brain implements a cognitive process. Identifying an appropriate model typically requires a great deal of effort and ingenuity on the part of a human scientist. Here, …
us, gb, de
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Yichun Shuai, Megan Sammons, Gabriella R Sterne, Karen L Hibbard et autres
The mushroom body (MB) is the center for associative learning in insects. In Drosophila , intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the foundation for precise interrogation of the MB neural circuits. However, investigation of many cell types upstream …
us
(code pays fourni par la source)
Accès ouvert
2025
peer-review
OpenAlex
Yichun Shuai, Megan Sammons, Gabriella R Sterne, Karen L Hibbard et autres
us
(code pays fourni par la source)
Accès ouvert
2025
peer-review
OpenAlex
Yichun Shuai, Megan Sammons, Gabriella R Sterne, Karen L Hibbard et autres
The mushroom body (MB) is the center for associative learning in insects. In Drosophila, intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the foundation for precise interrogation of the MB neural circuits. However, investigation of many cell types upstream and …
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Yichun Shuai, Megan Sammons, Gabriella R Sterne, Karen L Hibbard et autres
The mushroom body (MB) is the center for associative learning in insects. In Drosophila, intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the foundation for precise interrogation of the MB neural circuits. However, investigation of many cell types upstream and …
us
(code pays fourni par la source)
Accès ouvert
2024
peer-review
OpenAlex
Yichun Shuai, Megan Sammons, Gabriella R Sterne, Karen L Hibbard et autres
The mushroom body (MB) is the center for associative learning in insects. In Drosophila, intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the foundation for precise interrogation of the MB neural circuits. However, investigation of many cell types upstream and …
us
(code pays fourni par la source)
Accès ouvert
2024
preprint
OpenAlex
Yichun Shuai, Megan Sammons, Gabriella R Sterne, Karen L Hibbard et autres
Abstract The mushroom body (MB) is the center for associative learning in insects. In Drosophila, intersectional split-GAL4 drivers and electron microscopy (EM) connectomes have laid the foundation for precise interrogation of the MB neural circuits. However, investigation of many cell types upstream …
us, il
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Helen Farrants, Yichun Shuai, William C. Lemon, Christian Monroy Hernandez et autres
Abstract Genetically encoded fluorescent calcium indicators allow cellular-resolution recording of physiology. However, bright, genetically targetable indicators that can be multiplexed with existing tools in vivo are needed for simultaneous imaging of multiple signals. Here we describe WHaloCaMP, a modular chemigenetic calcium indicator …
us, de
(code pays fourni par la source)