Lutz Trojan

Verheerender Verlauf – gutes Ende! Exzellente Ergebnisse dank Implantation eines künstlichen Blasenschließmuskels trotz perinealer Urethrostomie – ein Fallbericht

Niklas Matthias Bohne, Roberto Olianas, Arne Strauß, Mirjam Naomi Mohr et autres

In this case report, we describe, for the first time, the implantation of an AMS-800 sphincter (Boston Scientific Corporation, Marlborough, MA, USA) in a patient with stress incontinence following radical prostatectomy, who was ultimately treated with an perineal urethrostomy due to a …

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Combined robot-assisted surgery of upper and lower genitourinary tract with excellent early functional and oncological outcome – a case report of a concomitant nerve-sparing radical prostatectomy, diverticulectomy and ureterectomy

Jan Lüdecke, Mirjam Naomi Mohr, T Schneider, Joost Wilhelm Voß et autres

INTRODUCTION AND IMPORTANCE: "Congenital anomalies of the kidney and urinary tract" (CAKUT) represent a heterogeneous and rare group of disorders affecting the urinary tract. Despite the widespread availability of ultrasound, the diagnosis of congenital urinary tract malformations is often made in adulthood. …

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Author Correction: Epidemiology, treatment and outcomes of primary renal sarcomas in adult patients

Johannes Uhlig, Annemarie Uhlig, Hari A. Deshpande, Philipp Ströbel et autres

Author notes These authors contributed equally: Johannes Uhlig and Annemarie Uhlig. Authors and Affiliations Department of Diagnostic and Interventional Radiology, University Medical Center Goettingen, Robert-Koch-Strasse 40, 37075, Göttingen, Germany Johannes Uhlig & Joachim Lotz Department of Diagnostic Radiology and Nuclear Imaging, University …

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Epidemiology, treatment and outcomes of primary renal sarcomas in adult patients

Johannes Uhlig, Annemarie Uhlig, Hari A. Deshpande, Philipp Ströbel et autres

To assess epidemiology, clinical presentation, treatment and overall survival of adult patients with renal sarcomas, the 2004-2016 SEER and NCDB databases were queried for adult patients diagnosed with renal sarcoma, calculating average annual age-adjusted incidence rates (AAIR) and average annual percentage change …

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Precise Prediction of Long-Term Urinary Incontinence after Robot-Assisted Laparoscopic Radical Prostatectomy by Readily Accessible “Everyday” Diagnostics during Post-Surgical Hospitalization

Mirjam Naomi Mohr, Hannah Maria Ploeger, Marianne Leitsmann, Conrad Leitsmann et autres

Aim and Objectives: We aimed to test the predictive value of readily accessible and easily performed post-surgical “bedside tests” on their validity of long-term urinary incontinence (UI) (≥12 months) in patients following robot-assisted laparoscopic radical prostatectomy (RALP). Material and Methods: Patients undergoing …

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Vergleich von Patientenbewertungen auf Online-Portalen untereinander und mit Qualitätsberichten der Krankenhäuser und der Qualitätssicherung mit Routinedaten

Conrad Leitsmann, Loraine Kahlmeier, Paul-Oliver Lampe, Christer Groeben et autres

BACKGROUND: In addition to the objectifiable treatment quality, patients' perspectives are gaining relevance. OBJECTIVE: This study aimed to characterize available hospital rating websites (HRW) with regards to patient ratings and to compare them with data from hospital quality reports and quality assurance …

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Personalized Treatment Strategy in “Low-Risk Prostate Cancer Active Surveillance Candidates” Using Irreversible Electroporation: Prospective Evaluation of Feasibility, Morbidity, Functional and Oncological Outcomes

Ionel Valentin Popeneciu, Mirjam Naomi Mohr, Arne Strauß, Conrad Leitsmann et autres

PURPOSE: To evaluate the morbidity, functional and oncological outcome of irreversible electroporation (IRE) as a focal therapy for prostate cancer (PCa) when used in "active surveillance (AS)" candidates refusing standard treatment options. MATERIALS AND METHODS: IRE was performed under general anaesthesia, and …

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Sunitinib for Metastatic Renal Cell Carcinoma: Real-World Data from the STAR-TOR Registry and Detailed Literature Review

Annemarie Uhlig, Lothar Bergmann, Martin Bögemann, Thomas Fischer et autres

INTRODUCTION: We evaluated the effectiveness and safety profile of the tyrosine kinase inhibitor sunitinib in patients with advanced or metastatic renal cell carcinoma (a/mRCC) in a real-world setting. METHODS: We analyzed data of adult a/mRCC patients treated with sunitinib. Data were derived …

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Funktionsprotektiver Verschluss einer urethrokutanen Fistel der prostatischen Harnröhre über einen perinealen Zugang mit Gracilis-Flap

Mathias Reichert, Adam Stepniewski, Marian Grade, Gunther Felmerer et autres

We present the case of a 36-year-old man suffering from perianal loss of urine through a cutaneous pore while urinating. Appropriate diagnostic investigation showed a urethrocutaneous fistula of the prostatic urethra of unclear aetiology. Because of the patient's young age and sexual …

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Impact of multiparametric magnetic resonance imaging targeted biopsy on functional outcomes in patients following robot-assisted laparoscopic radical prostatectomy

Conrad Leitsmann, Annemarie Uhlig, Felix Bremmer, Mirjam Naomi Mohr et autres

Introduction Multiparametric magnetic resonance imaging guided prostate biopsy (mpMRI PBx) leads to a higher rate of successful nerve-sparing in robot-assisted laparoscopic prostatectomy (ns-RALP) for prostate cancer (PCa). This study aimed to evaluate the impact of mpMRI PBx compared to standard ultrasound-guided PBx …

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Long time abiraterone treatment changes metabolism of VCaP cells towards ketogenesis, anaerobic glycolysis, accumulation of unsaturated fatty acids, and consecutively increased sensitivity to ferroptosis-inducing noxae

S. Okutoyi, Marina Bertlich, Abishek B. Santhakumar, Vivek Venkataramani et autres

Resistance to darolutamide in vitro correlates with global levels and occupancy patterns of histone modifications H3K27me3 and H3K27ac, depends on its regulator protein EZH2, and is at least partially mediated by Hedgehog signaling

Péter Schmidt, M. Podehl, Florian Wegwitz, S. Okutoyi et autres