Accès ouvert
2024
article
OpenAlex
Jannik Boos, Caspar I. van der Made, Gayatri Ramakrishnan, Eamon Coughlan et autres
Despite extensive global research into genetic predisposition for severe COVID-19, knowledge on the role of rare host genetic variants and their relation to other risk factors remains limited.Here, 52 genes with prior etiological evidence were sequenced in 1,772 severe COVID-19 cases and …
de, nl, gb, it, es
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Accès ouvert
2022
article
OpenAlex
Athanasios Kousathanas, Erola Pairo‐Castineira, Konrad Rawlik, Alex Stuckey et autres
after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically …
gb, au, cn, ca, ie, us, hk, Ouganda, br
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Accès ouvert
2021
article
OpenAlex
Chiara Fallerini, Nicola Picchiotti, Margherita Baldassarri, Kristina Zguro et autres
The combined impact of common and rare exonic variants in COVID-19 host genetics is currently insufficiently understood. Here, common and rare variants from whole-exome sequencing data of about 4000 SARS-CoV-2-positive individuals were used to define an interpretable machine-learning model for predicting COVID-19 …
it, se, fr, at, be, ca, gb, de
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Accès ouvert
2021
article
OpenAlex
Mari Niemi, Juha S. Karjalainen, Rachel G. Liao, Benjamin M. Neale et autres
Abstract The genetic make-up of an individual contributes to the susceptibility and response to viral infection. Although environmental, clinical and social factors have a role in the chance of exposure to SARS-CoV-2 and the severity of COVID-19 1,2 , host genetics may …
fi, us, es, de, it, gb, nl, ca, kr, jp, ae, fr, au, pl, in, be, qa, dk, cl, pr, mx
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Accès ouvert
2017
article
OpenAlex
Guy Edward Thwaites, Matthew Scarborough, Alexander J. Szubert, Emmanuel Fru Nsutebu et autres
BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci …
gb, vn
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