Accès ouvert
2026
article
OpenAlex
H. Wiendl, M. Mäurer, T. Berger, G. Bsteh et autres
de, at, ch
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Accès ouvert
2026
article
OpenAlex
Sumanta Barman, Saskia Räuber, Katharina Eisenhut, Daniela Esser et autres
The immunopathogenesis of autoimmune neurological syndromes (AINS) with antibodies against the 65 kDa isoform of glutamic acid decarboxylase (anti-GAD65 AINS) remains poorly understood. To elucidate underlying disease mechanisms and identify relevant cell populations, we performed single-cell RNA and immune repertoire sequencing of …
de, sk, nl, us, at
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Accès ouvert
2026
article
OpenAlex
Jonathan Wickel, Ha‐Yeun Chung, Franz Felix Konen, Rosa Rössling et autres
OBJECTIVES: The aim of this study was to analyze changes in hospital incidence cases and disease severity of autoantibody-associated autoimmune encephalitis (AE) during the COVID-19 pandemic compared with the prepandemic period. METHODS: A retrospective multicenter study analyzed data from 24 centers within …
de, sk, at
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Accès ouvert
2025
article
OpenAlex
Tobias R. Baumgartner, Moritz Freyberg, Lucia Campetella, Yvette S. Crijnen et autres
BACKGROUND AND OBJECTIVES: Autoimmune encephalitis (AIE) with anti-leucine-rich glioma-inactivated 1 (LGI1) antibodies typically manifests with subacute cognitive deficits, seizures, and psychiatric symptoms, mostly in older adults. Immunotherapy (IT) leads to the cessation of seizures in most patients, yet some develop AIE-associated epilepsy …
de, fr, nl, at, ch
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Accès ouvert
2025
article
OpenAlex
Andreas Alexander Schmid, Emily Wilfurth, Alexandra Höpfinger, Edita Islami et autres
Abstract GDF15 (growth/differentiation factor-15) belongs to the superfamily of transforming growth factor-beta. Little is known about adipocytic regulation of GDF15, its concentrations in serum and cerebrospinal fluid (CSF), its permeability to the brain, and its correlation with neurological diseases. This knowledge is …
de
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Accès ouvert
2025
article
OpenAlex
Thomas Grüter, Carles Gaig, Yvette S. Crijnen, Maarten J. Titulaer et autres
Importance: Anti-IgLON5 disease is an autoimmune encephalopathy that often leads to severe disability or death. The efficacy of immunotherapy remains unknown. Objective: To investigate whether early immunotherapy is associated with disability and death in anti-IgLON5 disease. Design, Setting, and Participants: This retrospective, …
de, es, nl, at, fr
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Accès ouvert
2025
article
OpenAlex
Marianna Cortese, Xiaojing Peng, Gilles Edan, Mark Steven Freedman et autres
BACKGROUND AND OBJECTIVES: Higher dietary intake of alpha-linolenic acid (ALA), a plant-derived omega-3 polyunsaturated fatty acid (PUFA), was associated with a lower risk of multiple sclerosis (MS) in a prospective cohort study and lower risk of new lesions, relapses, and disability progression …
us, fr, ca, de, es, nl, ch, gb
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Accès ouvert
2025
article
OpenAlex
Amelie Bohn, Klemens Angstwurm, Christian G. Bien, Kathrin Doppler et autres
BACKGROUND AND OBJECTIVES: Comorbidities greatly influence the course of many diseases. However, systematic data on comorbidities in patients with autoimmune encephalitis (AE) are scarce. We aimed to characterize comorbidities in patients with common AE variants and assess their influence on outcome and …
de
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Accès ouvert
2025
article
OpenAlex
Fynn Gurski, Kian Shirvanchi, Vinothkumar Rajendran, R. Rajendran et autres
Background and Purpose: FGF, VEGFR-2 and CSF1R signalling pathways play a key role in the pathogenesis of multiple sclerosis (MS). Selective inhibition of FGFR by infigratinib in MOG35-55-induced experimental autoimmune encephalomyelitis (EAE) prevented severe first clinical episodes by 40%; inflammation and neurodegeneration …
Accès ouvert
2024
article
OpenAlex
Alexandra Höpfinger, Andreas Alexander Schmid, Thomas Karrasch, Andreas Schäffler et autres
Background: Dysregulation of adipokines is considered a key mechanism of chronic inflammation in metabolic syndrome. Some adipokines affect food intake by crossing the blood/brain barrier. The adipokine chemerin is associated with metabolic syndrome, cardiovascular diseases and immune response. Little is known about …
de
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Accès ouvert
2024
article
OpenAlex
Fynn Gurski, Kian Shirvanchi, Vinothkumar Rajendran, R. Rajendran et autres
Abstract Background and Purpose FGF, VEGFR‐2 and CSF1R signalling pathways play a key role in the pathogenesis of multiple sclerosis (MS). Selective inhibition of FGFR by infigratinib in MOG 35‐55 ‐induced experimental autoimmune encephalomyelitis (EAE) prevented severe first clinical episodes by 40%; …
de
(code pays fourni par la source)
2024
preprint
OpenAlex
Fynn Gurski, Kian Shirvanchi, Vinothkumar Rajendran, R. Rajendran et autres
Background and Purpose: Fibroblast Growth Factor (FGF), VEGFR2, and CSF1R signalling pathways play a key role in the pathogenesis of multiple sclerosis (MS). Selective inhibition of FGFR by infigratinib in MOG35-55-induced EAE prevented severe first clinical episodes by 40%; inflammation and neurodegeneration …
de
(code pays fourni par la source)