Accès ouvert
2026
article
OpenAlex
Junfang Zhang, Lipeng Sun, Xinyuan Yang, Lin Kang et autres
White matter microstructural changes play a crucial role in cognitive decline in aging and neurodegenerative disorders including Alzheimer's disease (AD). However, the processes underlying white matter microstructural changes and the molecular pathways leading to these changes in AD remain largely unknown. AD …
cn, us, jp, cz, gb
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Accès ouvert
2025
article
OpenAlex
Liangyu Huang, Chen‐Chen Tan, Wei Xu, Lan Tan et autres
Progranulin (PGRN) and soluble triggering receptor expressed on myeloid cells-2 (sTREM2) are emerging biomarkers of Alzheimer’s disease (AD). This study explores the roles of their interplay in modulating amyloid pathology. We analyzed data from 905 participants (mean age = 62.0) in the …
cn, us, gb
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Accès ouvert
2025
article
OpenAlex
Yue Cai, Lili Fang, Jie Yang, Xin Zhou et autres
Importance: The impact of educational attainment (EA) on longitudinal tau accumulation remains largely underexplored. Objective: To investigate the association of EA with tau accumulation in Alzheimer disease (AD). Design, Setting, and Participants: This cohort study used 3 independent samples: the Alzheimer's Disease …
cn, hk, us
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Accès ouvert
2024
article
OpenAlex
Laura E.M. Wisse, Nicola Spotorno, Marcello Rossi, Michel J. Grothe et autres
Importance: The lack of an in vivo measure for α-synuclein (α-syn) pathology until recently has limited thorough characterization of its brain atrophy pattern, especially during early disease stages. Objective: To assess the association of state-of-the-art cerebrospinal fluid (CSF) seed amplification assays (SAA) …
se, it, es, us
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Accès ouvert
2024
article
OpenAlex
Eardi Lila, Wenbo Zhang, Swati Rane Levendovszky, William J. Jagust et autres
We introduce a novel framework for the classification of functional data supported on nonlinear, and possibly random, manifold domains. The motivating application is the identification of subjects with Alzheimer's disease from their cortical surface geometry and associated cortical thickness map. The proposed …
us
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Accès ouvert
2023
article
OpenAlex
Marc James Quesnel, Anne Labonté, Cynthia Picard, Henrik Zetterberg et autres
Insulin, insulin-like growth factors (IGF) and their receptors are highly expressed in the adult hippocampus. Thus, disturbances in the insulin-IGF signalling pathway may account for the selective vulnerability of the hippocampus to nascent Alzheimer's disease (AD) pathology. In the present study, we …
ca, us, se, gb, cn, fr
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Accès ouvert
2023
article
OpenAlex
Yi‐Ting Wang, Joseph Therriault, Stijn Servaes, Cécile Tissot et autres
Females are disproportionately affected by dementia due to Alzheimer's disease. Despite a similar amyloid-β (Aβ) load, a higher load of neurofibrillary tangles (NFTs) is seen in females than males. Previous literature has proposed that Aβ and phosphorylated-tau (p-tau) synergism accelerates tau tangle …
ca, se, gb, no, us
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Accès ouvert
2023
article
OpenAlex
Zahra Shirzadi, Stephanie A. Schultz, Wai‐Ying Wendy Yau, Nelly Joseph‐Mathurin et autres
Importance: Increased white matter hyperintensity (WMH) volume is a common magnetic resonance imaging (MRI) finding in both autosomal dominant Alzheimer disease (ADAD) and late-onset Alzheimer disease (LOAD), but it remains unclear whether increased WMH along the AD continuum is reflective of AD-intrinsic …
us, de, au, gb, jp, es, kr, ca
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Accès ouvert
2023
article
OpenAlex
Jun Pyo Kim, Paula J. Bice, Kevin Huynh, Tingting Wang et autres
BACKGROUND: Deep learning has shown potential in various scientific domains but faces challenges when applied to complex, high-dimensional multi-omics data. Alzheimer's Disease (AD) is a neurodegenerative disorder that lacks targeted therapeutic options. This study introduces the Circular-Sliding Window Association Test (c-SWAT) to …
us, kr, au, de
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Accès ouvert
2023
article
OpenAlex
Cosimo Tuena, Sara Maestri, Silvia Serino, Elisa Pedroli et autres
BACKGROUND: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer's Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however further studies are needed. The aim of this …
it
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Accès ouvert
2023
article
OpenAlex
Tiago Azevedo, Richard A. I. Bethlehem, David J. Whiteside, Nol Swaddiwudhipong et autres
BACKGROUND: Identifying prediagnostic neurodegenerative disease is a critical issue in neurodegenerative disease research, and Alzheimer's disease (AD) in particular, to identify populations suitable for preventive and early disease-modifying trials. Evidence from genetic and other studies suggests the neurodegeneration of Alzheimer's disease measured …
gb, us
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Accès ouvert
2023
article
OpenAlex
Emma McLachlan, Dilek Ocal, Neil Burgess, Suzanne Reeves et autres
Importance: Understanding the mechanisms of delusion formation in Alzheimer disease (AD) could inform the development of therapeutic interventions. It has been suggested that delusions arise as a consequence of false memories. Objective: To investigate whether delusions in AD are associated with false …
gb, us
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