Αnastasia Kotanidou

Evaluation of Longitudinal CD40 and CD40L Changes During Adjuvant Breast Cancer Therapy and Their Association with Left Ventricular Dysfunction

Georgia Efthymiou, Maria Anastasiou, Evangelos K. Oikonomou, Panagiotis Theofilis et autres

Background: Left ventricular (LV) dysfunction is a clinically important complication of anthracycline- and trastuzumab-based treatment in breast cancer. Inflammatory pathways may contribute to cancer therapy-related cardiac dysfunction, and the CD40/CD40 ligand (CD40L) axis has been implicated in vascular inflammation and myocardial injury. …

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Novel Adipokines in Critical Illness and Sepsis: Chemerin, Vaspin, and Omentin-1: A Comprehensive Evidence-Based Review

Vassiliki Giannopoulou, Kostas A. Papavassiliou, Nikolaos S. Lotsios, Matina Kardara et autres

Adipose tissue has emerged as a pivotal endocrine organ, secreting bioactive proteins termed adipokines that regulate metabolic and immune processes across multiple organ systems. In the context of sepsis and critical illness, conditions defined by a dysregulated host response to infection with …

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Novel Adipokines in Critical Illness and Sepsis: Chemerin, Vaspin, and Omentin-1. A Comprehensive Evidence-Based Review

Vassiliki Giannopoulou, Kostas A. Papavassiliou, Nikolaos S. Lotsios, Matina Kardara et autres

Adipose tissue has emerged as a pivotal endocrine organ, secreting bioactive proteins termed adipokines that regulate metabolic and immune processes across multiple organ systems. In the context of sepsis and critical illness, conditions defined by a dysregulated host response to infection with …

Circulating Novel Adipokines in Critically Ill Patients with and Without Sepsis

Vassiliki Giannopoulou, Ioannis Ilias, Chrysi Keskinidou, Charikleia S. Vrettou et autres

Background/Objectives: Adipokines are candidate biomarkers in critical illness due to their roles in immunity and metabolism, both profoundly altered in sepsis. Omentin-1, vaspin, and chemerin have been studied in selected septic cohorts, but not concurrently in a heterogeneous ICU population including both …

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Temporal Aquaporin Expression Profiles in Immune Cell Subsets During Critical Illness

Nikolaos S. Lotsios, Vasileios Issaris, Georgios Poupouzas, Charikleia S. Vrettou et autres

Aquaporins (AQPs) are a family of water channel proteins with a significant role in immune cell function. Although AQPs have been studied in sepsis, their expression in critical illness remains underexplored. Our group aimed to examine the mRNA expression profile of AQP …

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Perpetual observational study of the clinical and microbiological epidemiology of ventilator-associated pneumonia in Europe

Holly Jackson, Ana Catalina Hernandez Padilla, Lisanne E. M. Vintcent, Aleksandra M. Barac et autres

BACKGROUND: The clinical and microbiological epidemiology of ventilator-associated pneumonia (VAP) is not well studied in intensive care units (ICUs) European wide. The European Clinical Research Alliance on Infectious Diseases (Ecraid), a warm-base clinical research network investigating infectious diseases, aimed to track the …

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Efficacy, safety, pharmacokinetics, immunogenicity, and serum neutralizing activity of AZD7442 (tixagevimab-cilgavimab) in patients hospitalized with COVID-19: long-term results from the DisCoVeRy trial

Clément Massonnaud, Nathan Peiffer‐Smadja, Pascal Poignard, Simon Jamard et autres

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Effect of Decay-accelerating Factor on LPS-induced Acute Lung Injury in the Rat

Maria G. Detsika, Ioanna Nikitopoulou, Stylianos E. Orfanos, Ioanna Dimopoulou et autres

Background/Aim: Complement activation has been implicated as a contributor to lung injury. Membrane-bound complement regulatory proteins, including decay-accelerating factor (DAF), control complement activation, thus mitigating complement-mediated injury. Their effect on lung injury remains unexplored. Using a DAF knockout rat model, we assessed …

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Low DLCO Can Provide Insights into Treatment Response in PAH Patients Irrespective of the Reason for Its Decrease

Effrosyni Dima, Stylianos E. Orfanos, Vasileios Grigoropoulos, Dimitra Fasfali et autres

Group 1 of PAH patients encompasses patients with a diverse underlying etiological condition, having histological modifications that can affect gas exchange across the alveolar-capillary membrane, as reflected by decreased DLCO. Values of DLCO did not identify the exact reason for their decrease, …

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Low DLCO Can Provide Insights into Treatment Response in PAH Patients Irrespectively of the Reason of Its Decrease

Effrosyni Dima, Stylianos E. Orfanos, Vasileios Grigoropoulos, Dimitra Fasfali et autres

Group of PAH patients encompasses patients with a diverse underlying aetiological condition, having histological modifications that can affect gas exchange across the alveolar-capillary membrane as it is reflected by decreased DLCO. DLCO values did not identify the exact reason of its decrease, …

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Analgesic and Neuroprotective Roles of Dexmedetomidine in Spine Surgery: A Systematic Review

Spyridoula Roberta Afrati, Ioanna Lianou, Angelos Kaspiris, Vasileios Marougklianis et autres

OBJECTIVES: The incidence of postoperative pain in patients that undergo spinal interventions is significantly increased, affecting their functional outcomes and quality of life. Dexmedetomidine (DEX) belongs to the category of centrally acting nonopioid agents with highly selective α2 adrenoreceptor agonist activity that …

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Disrupting the Complex BMP/TGF-β Signaling Pathway: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells

Chrysi Keskinidou, Nikolaos S. Lotsios, Kostas A. Papavassiliou, Ioanna Dimopoulou et autres

Pulmonary arterial hypertension (PAH) is a chronic disorder with high fatality rates, and its progression is highly associated with the genetic background. Alongside pathogenic variants in genes central to the BMP/TGF-β signaling pathway, recent evidence has linked aquaporin 1 (AQP1) gene variants …

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