Peder Skov Wehner

Central nervous system penetration of imatinib in acute lymphoblastic leukemia: Pharmacokinetic analysis and clinical implications

Annie Rasmussen, Cecilie Utke Rank, Ib Jarle Christensen, Allan Weimann et autres

PURPOSE: Tyrosine kinase inhibitors (TKIs) have improved outcomes in Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) and are increasingly incorporated into treatment protocols of Philadelphia chromosome-like (Ph-like, ABL-class) ALL. However, central nervous system (CNS) relapse remains a significant challenge. Imatinib, a first-generation …

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Pulmonary Function Deficit and Clinical Associations in Childhood Acute Lymphoblastic Leukaemia Survivors: A National Retrospective ALL‐STAR Lungs Cohort Study

Sonja Izquierdo Riis Meyer, Birgitte Klug Albertsen, Mette Tiedemann Skipper, Ruta Tuckuviene et autres

BACKGROUND: Although survival for childhood acute lymphoblastic leukaemia (ALL) has improved, long-term pulmonary function deficit remains a concern. We aimed to explore the prevalence of pulmonary function deficit and abnormal pulmonary function tests in childhood ALL survivors and clinical associations. METHODS: This …

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Radiotherapy Delivery in Deep Inspiration for Pediatric Patients—Final Results of the Phase II Feasibility Study TEDDI

Daniella Elisabet Østergaard, Anni Young Lundgaard, Laura Ann Rechner, Danijela Dejanović et autres

INTRODUCTION: The TEDDI trial tested the feasibility and reproducibility of deep-inspiration breath-hold (DIBH) in pediatric patients referred for radiotherapy. This report presents final results, including patient-reported outcomes (PRO) and dosimetric comparison of DIBH and free-breathing (FB). PATIENTS AND METHODS: Pediatric patients able …

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Data from Childhood Cancer Predisposition and Evolutionary Constraints: Novel Lessons from Germline Genomes from 1,127 Children with Cancer

Ulrik Kristoffer Stoltze, Thomas van Overeem Hansen, Jon Foss-Skiftesvik, Anna Byrjalsen et autres

AbstractPurpose: Cancer predisposition syndromes (CPS) with pediatric onset are the leading known cause of childhood malignancies and are increasingly guiding clinical strategies in pediatric oncology. CPS are placed under evolutionary negative selective pressure, but pediatric pancancer studies have so far failed to …

Supplementary Data 2 from Childhood Cancer Predisposition and Evolutionary Constraints: Novel Lessons from Germline Genomes from 1,127 Children with Cancer

Ulrik Kristoffer Stoltze, Thomas van Overeem Hansen, Jon Foss-Skiftesvik, Anna Byrjalsen et autres

Supplementary Dataset combined

Supplementary Data 1 from Childhood Cancer Predisposition and Evolutionary Constraints: Novel Lessons from Germline Genomes from 1,127 Children with Cancer

Ulrik Kristoffer Stoltze, Thomas van Overeem Hansen, Jon Foss-Skiftesvik, Anna Byrjalsen et autres

Supplementery Results and Methods

Physical Functioning Report and Pulmonary Function Deficit in Childhood and Adolescent Acute Lymphoblastic Leukemia Survivors: A National Cross‐Sectional ALL‐STAR Lungs Study

Sonja Izquierdo Riis Meyer, Mette Tiedemann Skipper, Birgitte Klug Albertsen, Ruta Tuckuviene et autres

BACKGROUND: Childhood acute lymphoblastic leukemia (ALL) survivors face an increased risk of pulmonary function deficit (PFD), which may affect physical functioning. We aimed to evaluate parent proxy- and self-reported physical functioning and the association with PFD and abnormal bronchodilator response ( + …

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Late pulmonary adverse effects in childhood and adolescent acute lymphoblastic leukaemia survivors: a cross-sectional ALL-STAR Lungs study

Sonja Izquierdo Riis Meyer, Mette Tiedemann Skipper, Birgitte Klug Albertsen, Ruta Tuckuviene et autres

Background Childhood acute lymphoblastic leukaemia (ALL) survival rates have improved, reaching 95%. However, 25–50% of survivors experience significant treatment-related toxicities. This study investigated late pulmonary adverse effects, including pulmonary symptoms and pulmonary function, in childhood ALL survivors compared to controls. Methods This …

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Childhood Cancer Predisposition and Evolutionary Constraints: Novel Lessons from Germline Genomes from 1,127 Children with Cancer

Ulrik Kristoffer Stoltze, Thomas van Overeem Hansen, Jon Foss-Skiftesvik, Anna Byrjalsen et autres

PURPOSE: Cancer predisposition syndromes (CPS) with pediatric onset are the leading known cause of childhood malignancies and are increasingly guiding clinical strategies in pediatric oncology. CPS are placed under evolutionary negative selective pressure, but pediatric pancancer studies have so far failed to …

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Flow cytometric analysis of cerebrospinal fluid identifies patients with occult central nervous system involvement in relapsed pediatric acute lymphoblastic leukemia

Ole Thastrup, Hanne Vibeke Marquart, Mette Levinsen, Aina Ulvmoen et autres

Not available.

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Risk of Metabolic Syndrome and Glucose Homeostasis Among Childhood and Young Adult Acute Lymphoblastic Leukemia Survivors: Part of the ALL‐STAR Study

Mette Tiedemann Skipper, Niels Birkebæk, Rikke Beck Jensen, Bente Lomholt Langdahl et autres

BACKGROUND: Metabolic syndrome (MetS), a risk factor for early cardiovascular morbidity and mortality, is seen in up to 34% of survivors of childhood acute lymphoblastic leukemia (ALL). PROCEDURE: We performed a Danish, national cross-sectional study of ALL survivors (aged 1-45 years at …

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Relapse and survival after relapse among children with cancer in Denmark: 2001–2021

Mie M. Andersen, Marie Christine Lundius Sørensen, Kjeld Schmiegelow, Astrid Marie Sehested et autres

BACKGROUND: In recent decades, new first and subsequent lines of anticancer treatment and supportive care have improved survival for children with cancer. We investigated recent temporal changes in the incidence of relapse and survival after relapse among children with cancer in Denmark. …

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