Steven Kyle Grinspoon

Prognostic value of pericoronary adipose tissue on ECG-gated non-contrast CT in patients with stable chest pain: insights from the PROMISE trial

Marcel Christian Langenbach, Ibrahim Hadžić, Isabel L. Langenbach, Thomas Mayrhofer et autres

AIMS: To investigate whether computed tomography (CT)-derived pericoronary adipose tissue (PCAT) metrics are associated with coronary artery disease (CAD) characteristics and adverse cardiovascular outcomes in patients with stable chest pain. METHODS AND RESULTS: PCAT attenuation and body surface area-indexed PCAT volume were …

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Hypertension Prevalence and Control at Trial Entry in the REPRIEVE Study Population: Results From a Secondary Analysis

Risa M. Hoffman, Maya Watanabe, Estebán Martínez, Markella V. Zanni et autres

Background: We evaluated baseline hypertension prevalence and control and risk of major adverse cardiovascular events (MACEs) among people with HIV in REPRIEVE who had low to moderate traditional cardiovascular disease (CVD) risk. Methods: Hypertension at baseline was defined by (1) a preexisting …

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Pitavastatin effects on lipids in relation to major adverse cardiovascular events: a REPRIEVE secondary analysis

Triin Umbleja, Mohammad Urooj Zafar, Sara McCallum, Arijeet K. Gattu et autres

BACKGROUND: The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) found a 36% reduction in major adverse cardiovascular events (MACE) with pitavastatin in people with HIV. Little is known about the relationship between lipid lowering and MACE in this population. We …

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Risk of obesity, diabetes, hypertension, and major adverse cardiovascular events after a switch to an integrase inhibitor: a target trial emulation in REPRIEVE

Emma M. Kileel, Carlos Malvestutto, Markella V. Zanni, Emma Davies-Smith et autres

BACKGROUND: Integrase strand-transfer inhibitors (INSTIs) are linked to weight gain, but data on their cardiometabolic effects, particularly major adverse cardiovascular events (MACE), are scarce. We aimed to estimate the risk of obesity, diabetes, hypertension, and MACE after switching to an INSTI in …

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Muscle movement and metabolism: exercise and skeletal muscle as mediators of health—a report from the 26th Annual Harvard Nutrition Obesity Symposium, 2025

Lauren Carollo, Elizabeth Austen Lawson, Takara Leah Stanley, Jingyu Wang et autres

Skeletal muscle is a crucial facilitator of many of the effects of exercise on metabolic health. Intrinsic myocellular mechanisms, exercise-induced myokine secretion, and crosstalk between multiple organ systems contribute to the maintenance of energy homeostasis, cardiovascular health, strength, cognition, and quality of …

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Molecular insights in HIV-associated cardiac dysfunction

María Valero-Muñoz, Eng Leng Saw, David Richard Pimentel, Adam C. Gower et autres

Antiretroviral therapy (ART) in human immunodeficiency virus (HIV) markedly improved life expectancy in persons living with HIV (PLWH), but cardiac disease has emerged as the leading cause of death in this population. The prevalence of impaired diastolic function and heart failure with …

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Heart Failure Risk and Events in People With HIV: The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE)

Gerald S. Bloomfield, Maya Watanabe, Sara McCallum, Judith A. Aberg et autres

BACKGROUND: People with HIV (PWH) may have a higher risk of heart failure (HF) due to traditional and HIV-related factors. Incidence and risk prediction of HF in PWH are not well characterized. We aimed to quantify the risk of HF events in …

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Baseline ECG and Cardiovascular Outcomes in People With HIV: Insights From REPRIEVE

Aya Awwad, Christopher R. deFilippi, Heather Jane Ribaudo, Markella V. Zanni et autres

BACKGROUND: With antiretroviral therapy, people with HIV (PWH) have an increased burden of cardiovascular disease. The REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV) trial demonstrated that pitavastatin reduces major adverse cardiovascular events (MACEs) among PWH at low to moderate traditional …

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The effect of low-dose methotrexate on arterial inflammation in persons living with human immunodeficiency virus: A double-blind randomized placebo-controlled pilot trial

Ahmed Tawakol, Heather Jane Ribaudo, Ashley McKhann, Jamie W. Bellinge et autres

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Statin Effects on Pericoronary Adipose Tissue Density in People With HIV

Borek Foldyna, Ibrahim Hadžić, Thomas Mayrhofer, Júlia Karády et autres

BACKGROUND: The effects of statin therapy on pericoronary adipose tissue (PCAT) and its relationship with plaque progression and outcomes in people with HIV (PWH) remain poorly understood. OBJECTIVES: The aim of this study was to evaluate PCAT density changes over time; statin …

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Health-related quality of life among people with HIV at low-to-moderate risk for atherosclerotic cardiovascular disease in the REPRIEVE Trial

Marissa R Diggs, Sarah M Chu, Kathleen V. Fitch, Maxine Olefsky et autres

BACKGROUND: There is limited evidence concerning the relationship between cardiometabolic characteristics and health-related quality of life (HRQoL), and potential effects of statin therapy among people with HIV (PWH). METHODS: The Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE) enrolled PWH aged …

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Clonal Hematopoiesis and Major Adverse Cardiac Events in People With HIV: Insights From the REPRIEVE Trial

Liying Xue, Romit Bhattacharya, Md Mesbah Uddin, Tetsushi Nakao et autres

BACKGROUND: People with HIV (PWH) experience higher cardiovascular disease event rates not fully explained by traditional risk factors. Clonal hematopoiesis of indeterminate potential (CHIP), an emerging risk factor for cardiovascular disease in the general population, has been reported to be more prevalent …

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