Gilles Ivaldi

INDAGA PROJECT: RADIOBIOLOGICAL CHARACTERIZATION OF SALIVARY GLAND CANCER CELL LINES EXPOSED TO PHOTON AND PARTICLE IRRADIATION

Alexandra Charalampopoulou, Sara Borgna, Andrea Abate, Anna Bellini et autres

highlight the need for advanced 3D models to achieve a more accurate biological interpretation of BNCT selectivity in HNSCC.

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Cell Line-Dependent Spatial Organization of Hypoxic And Proliferative Regions Shapes Radiation Response in 3D Tumour Spheroids

Alexandra Charalampopoulou, Fabrizio De Luca, Giorgio Butella, Giuseppe Magro et autres

DISTINCT TRANSCRIPTOMIC PROGRAMS OF DNA DAMAGE, HYPOXIA, AND IMMUNE RESPONSE ELICITED BY LOW- VS HIGH-LET RADIOTHERAPY IN OVARIAN CANCER CELLS

Amelia Barcellini, Maurizio Polano, Alexandra Charalampopoulou, Giorgia Mangili et autres

Background and Aims: Head and neck cancer is the 6th most common cancer worldwide, with oral cavity cancer comprising approximately half of these cases.Nearly all oral cavity cancers originate from stratified squamous epithelium and are classified as oral squamous cell carcinomas (OSCCs).Conventional …

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A Novel α-Globin Gene Variant: Hb Romagna [α61(E10)Lys>Gln; HBA1:c.184A>C] Co-Inherited with Hb A2-Lampang [δ47(CD6)Asp>Asn; HBD:c.142G>A] in an Italian Diabetic Woman

Marco Rosetti, Giovanni Poletti, Melania Olivieri, Massimo Mogni et autres

Background: Screening for hemoglobinopathies, particularly in Mediterranean countries, is primarily aimed at preventing beta-thalassemia. However, during such screening, numerous other Hb defects can be diagnosed, each with different clinical significance, including qualitative and quantitative variations in the alpha genes. Aims: In the …

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Temporal and spatial patterns of γH2AX signaling in different human cells after exposure to X-rays and UV-C light

Isabella Guardamagna, Leonardo Lonati, Ombretta Iaria, A. Mentana et autres

Abstract The phosphorylation of H2AX at serine 139 (γH2AX) is a marker of DNA damage response, well characterized after ionizing radiation (IR) exposure. In this work we compared γH2AX activation in different human cell lines exposed to X-rays, up to 5 Gy, …

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TARGETING GLIOBLASTOMA IN 3D: HOW PHOTON AND CARBON ION RADIATION INFLUENCE TUMOUR SPHEROID BEHAVIOUR

Alexandra Charalampopoulou, Fabrizio De Luca, Niloufar Matoor, Amelia Barcellini et autres

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Familial erythrocytosis and phenotypic heterogeneity associated with different defects in alpha globin genes: a significant new case of Hb Wroclaw (α88(F9) Ala>Glu; HBA1 : c.266C>A)

Valentina Carrai, Cristina Giubbilei, Tiziana Biagioli, Massimo Maffei et autres

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COMBINATORIC : Carbon Ion Boost With Photons or Protons in Salivary Gland and Sinonasal Cancers

Anna Maria Camarda, Giulia Fontana, Barbara Vischioni, Amelia Barcellini et autres

AIM: To evaluate the outcomes of combining carbon ion radiotherapy boost (CIRTb) with photons (Ph) or protons (PT) for locally advanced salivary gland and sinonasal cancers (SGCs and SNCs). MATERIALS AND METHODS: Sixty-nine patients with SGCs and SNCs received CIRTb to high-risk …

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Quality of radiation shapes survival, invasiveness, and migration in ovarian cancer cell lines with different molecular profiles and varying alpha/beta ratios: an in vitro study on behalf of the Multicenter Italian Trials in Ovarian Cancer (MITO) group

Amelia Barcellini, Alexandra Charalampopoulou, Gustavo Baldassarre, Sandro Pignata et autres

Objective The results of radiotherapy (RT) in oligometastatic ovarian cancers (OCs) lead to the query whether it is possible to stratify patients based on tumor hallmarks to ensure the best-personalized RT treatment. To address this question, we designed a preclinical study to …

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Additional Cover

Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla et autres

Cover legend: The cover image is based on the article A Xanthine Derivative With Novel Heat Shock Protein 90-Alpha Inhibitory and Senolytic Properties by Sandra Atlante et al., https://doi.org/10.1111/acel.70047.

A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties

Sandra Atlante, Luca Cis, Davide Pirolli, Michela Gottardi Zamperla et autres

The accumulation of senescent cells contributes to aging and related diseases; therefore, discovering safe senolytic agents-compounds that selectively eliminate senescent cells-is a critical priority. Heat shock protein 90 (HSP90) inhibitors (HSP90i), traditionally investigated for cancer treatment, have shown potential as senolytic agents. …

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Does The Molecular Profile Of Ovarian Tumors Influence The Response To Radiotherapy? An In Vitro Study On Behalf Of Multicenter Italian Trials In Ovarian Cancer (MITO) Group

Amelia Barcellini, Alexandra Charalampopoulou, Gustavo Baldassarre, Sandro Pignata et autres

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