Rensheng Wang

Efficacy of PD-1 inhibitor plus induction chemotherapy for nasopharyngeal carcinoma with high-grade extranodal extension: a multicenter retrospective analysis

Pingting Zhou, Shuang Huang, Yunxiu Luo, Yuefeng Hu et autres

BACKGROUNDS: High-grade radiologic extranodal extension (G2/3-rENE) is a well-established adverse prognostic factor in nasopharyngeal carcinoma (NPC), as demonstrated in our previous research. This study aims to evaluate the efficacy and safety of combining a PD-1 inhibitor with induction chemotherapy (IC) in this …

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Evaluating the Causal Relationship Between Carnitine-Related Metabolites and Breast Cancer: A Mendelian Randomization and Transcriptomic Analysis

Feifeng Ran, Lilin Que, Lan Luo, Mei Qi Gan et autres

Introduction: Breast cancer (BC) is the most common malignancy among women worldwide. Although observational studies have linked carnitine-related metabolites (CRMs) to BC, causal inference has been limited by confounding and reverse causality. This study used Mendelian randomization (MR) analysis to investigate the …

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Integrated single-cell and transcriptomic analysis of CD8+CD101+TIM3+ T cells in hepatocellular carcinoma: implications for tumor microenvironment and prognostic modeling

Feifeng Ran, Zhang Jiang, Lilin Que, Lan Luo et autres

Background: Hepatocellular carcinoma (HCC) ranks as a leading global cause of cancer-related mortality. Our study investigates the functional role between CD8+CD101+TIM3+ T cells (CCT) and CD8+CD101−TIM3+ T cells in HCC, with a focus on their implications for immunotherapy. Methods: We utilized single-cell …

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Dosimetric Comparison of Intracavitary Versus Combined Intracavitary-Interstitial Image-Guided Brachytherapy in Locally Advanced Cervical Cancer

Xi Yang, Bo Zhao, Guiyong Yu, Zhuokai He et autres

Purpose The present study aimed to compare the dose distributions between conventional three-catheter intracavitary (IC) brachytherapy and combined intracavitary–interstitial (IC/IS) brachytherapy in the management of locally advanced cervical cancer (LACC). Materials and Methods A retrospective dosimetric analysis was performed using data from …

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Anti–LAG-3 Antibody LBL-007 plus Tislelizumab and Chemotherapy as First-Line Therapy for Advanced Nasopharyngeal Carcinoma: A Multicenter Phase 2 Trial

Dongchen Sun, Gang Chen, Yu Chen, Song Qu et autres

PURPOSE: Prior studies reported synergistic antitumor activity by dual inhibition of lymphocyte activation gene-3 (LAG-3) and PD-1. This study investigated the activity, safety, and biomarker of LAG-3/PD-1 co-blockade plus chemotherapy as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma (RM-NPC). PATIENTS AND …

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A lactylation-ferroptosis cross-talk gene signature predicts hepatocellular carcinoma prognosis and reveals STMN1/PRDX1 as therapeutic targets

Jiali Meng, Ling Li, Qiqi Huang, Weimei Huang et autres

Introduction: Hepatocellular carcinoma (HCC) presents great difficulties for diagnosis and prognosis. Metabolic reprogramming and ferroptosis resistance play critical roles in HCC development and progression. Methods: We combined transcriptome data from TCGA-LIHC to screen out lactylation-ferroptosis-related genes (LFRGs). Based on LASSO-Cox regression and …

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Performance of S π RIT TPC gating grid driver

S. Tangwancharoen, Taras Lokotko, W. G. Lynch, Olivia Gunter et autres

Author response for "Predictive Effect of Prognostic Nutritional Index on Lymph Node Regression Rate in Patients with Locally Advanced Nasopharyngeal Carcinoma Undergoing Concurrent Chemoradiotherapy"

JunMei Song, Ting Liu, YaJing Wen, YuQing Lv et autres

Predictive Effect of Prognostic Nutritional Index on Lymph Node Regression Rate in Patients with Locally Advanced Nasopharyngeal Carcinoma Undergoing Concurrent Chemoradiotherapy

JunMei Song, Ting Liu, YaJing Wen, YuQing Lv et autres

ObjectiveDetermining reliable predictive indicators of therapeutic efficacy for patients with nasopharyngeal carcinoma (NPC) can help select those who will benefit the most from treatment. This research assessed the predictive significance of the prognostic nutritional index (PNI) in patients with locally advanced nasopharyngeal …

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International Consensus Guideline on Delineation of the Clinical Target Volumes at Different Dose Levels for Nasopharyngeal Carcinoma (2024 Version)

Shaojun Lin, Qiaojuan Guo, Qin Liu, Wai Tong Ng et autres

PURPOSE: Radiation therapy planning for nasopharyngeal carcinoma is one of the most challenging tasks for radiation oncologists due to the notoriously narrow therapeutic margin. The first International Guideline (IG-2018 Version) has served as a practical guide for contouring clinical target volumes (CTVs). …

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Prognostic implications of alternative splicing events and key splicing factors in head and neck squamous cell carcinoma

Siyi He, Jiali Meng, Chunyan Liang, Yiru Wang et autres

The incidence of head and neck squamous cell carcinoma (HNSCC) remains high, accompanied by low 5-year survival rates. Identifying prognostic factors is essential for advancing personalized treatment approaches. Increasing evidence implicates aberrant alternative splicing (AS) plays a key role in tumor progression. …

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Prognostic value of prognostic nutritional index in patients with nasopharyngeal carcinoma treated with endostar and concurrent chemoradiotherapy

JunMei Song, Ting Liu, Qiulin Huang, YuQing Lv et autres

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