Sooriya Kannan Selvam

Optimizing mouse models for mRNA vaccines: addressing dose translation challenges

Zi Wei Chang, Yong Jie Tan, Yiyu Liao, Yun Shan Goh et autres

The development of mRNA vaccines has significantly advanced global health during the COVID-19 pandemic. However, translating effective vaccine doses from preclinical animal models to human clinical use remains poorly understood. In this study, we evaluated antibody responses and repertoire diversity across different …

sg (code pays fourni par la source)

Variant-Specific IgA Protects Against Omicron Infection

Yun Shan Goh, Siew‐Wai Fong, Pei Xiang Hor, Chiew Yee Loh et autres

BACKGROUND: The emergence of rapidly evolving severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, coupled with waning vaccine-induced immunity, has contributed to the rise of vaccine breakthrough infections. It is crucial to understand how vaccine-induced protection is mediated. METHODS: We examined 2 …

sg, in, gb (code pays fourni par la source)

Heterologous mRNA vaccine boosters induce a stronger and longer-lasting antibody response against Omicron XBB variant

Matthew Zirui Tay, Yun Shan Goh, Siew‐Wai Fong, Zi Wei Chang et autres

sg, gb (code pays fourni par la source)